Next Article in Journal
Clinical Routine and Necessary Advances in Soft Tissue Tumor Imaging Based on the ESSR Guideline: Initial Findings
Previous Article in Journal
Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-13C]pyruvate MRI
Previous Article in Special Issue
Follow-Up CT Patterns of Residual Lung Abnormalities in Severe COVID-19 Pneumonia Survivors: A Multicenter Retrospective Study
Article

Quantitative Chest CT Analysis to Measure Short-Term Sequelae of COVID-19 Pneumonia: A Monocentric Prospective Study

1
Department of Diagnostic and Interventional Radiology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy
2
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy
3
Department of Infectious Diseases, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Pietro Andrea Bonaffini and Clarissa Valle
Tomography 2022, 8(3), 1578-1585; https://doi.org/10.3390/tomography8030130
Received: 5 April 2022 / Revised: 31 May 2022 / Accepted: 14 June 2022 / Published: 17 June 2022
(This article belongs to the Special Issue The Challenge of Advanced Medical Imaging Data Analysis in COVID-19)
(1) Background: Quantitative CT analysis (QCT) has demonstrated promising results in the prognosis prediction of patients affected by COVID-19. We implemented QCT not only at diagnosis but also at short-term follow-up, pairing it with a clinical examination in search of a correlation between residual respiratory symptoms and abnormal QCT results. (2) Methods: In this prospective monocentric trial performed during the “first wave” of the Italian pandemic, i.e., from March to May 2020, we aimed to test the relationship between %deltaCL (variation of %CL-compromised lung volume) and variations of symptoms-dyspnea, cough and chest pain-at follow-up clinical assessment after hospitalization. (3) Results: 282 patients (95 females, 34%) with a median age of 60 years (IQR, 51–69) were included. We reported a correlation between changing lung abnormalities measured by QCT, and residual symptoms at short-term follow up after COVID-19 pneumonia. Independently from age, a low percentage of surviving patients (1–4%) may present residual respiratory symptoms at approximately two months after discharge. QCT was able to quantify the extent of residual lung damage underlying such symptoms, as the reduction of both %PAL (poorly aerated lung) and %CL volumes was correlated to their disappearance. (4) Conclusions QCT may be used as an objective metric for the measurement of COVID-19 sequelae. View Full-Text
Keywords: COVID-19; lung diseases; computed tomography; quantitative CT COVID-19; lung diseases; computed tomography; quantitative CT
Show Figures

Figure 1

MDPI and ACS Style

Lanza, E.; Ammirabile, A.; Casana, M.; Pocaterra, D.; Tordato, F.M.P.; Varisco, B.; Lisi, C.; Messana, G.; Balzarini, L.; Morelli, P. Quantitative Chest CT Analysis to Measure Short-Term Sequelae of COVID-19 Pneumonia: A Monocentric Prospective Study. Tomography 2022, 8, 1578-1585. https://doi.org/10.3390/tomography8030130

AMA Style

Lanza E, Ammirabile A, Casana M, Pocaterra D, Tordato FMP, Varisco B, Lisi C, Messana G, Balzarini L, Morelli P. Quantitative Chest CT Analysis to Measure Short-Term Sequelae of COVID-19 Pneumonia: A Monocentric Prospective Study. Tomography. 2022; 8(3):1578-1585. https://doi.org/10.3390/tomography8030130

Chicago/Turabian Style

Lanza, Ezio, Angela Ammirabile, Maddalena Casana, Daria Pocaterra, Federica M.P. Tordato, Benedetta Varisco, Costanza Lisi, Gaia Messana, Luca Balzarini, and Paola Morelli. 2022. "Quantitative Chest CT Analysis to Measure Short-Term Sequelae of COVID-19 Pneumonia: A Monocentric Prospective Study" Tomography 8, no. 3: 1578-1585. https://doi.org/10.3390/tomography8030130

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop