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Volume 8
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10.3390/tomography8020046
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Article

Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment

by
Ricarda von Krüchten
1,
Susanne Rospleszcz
2,3,
Roberto Lorbeer
4,
Dunja Hasic
1,
Annette Peters
2,3,5,
Fabian Bamberg
1,
Holger Schulz
2,
Stefan Karrasch
3,6,7 and
Christopher L. Schlett
1,*
1
Department of Diagnostic and Interventional Radiology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
2
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
3
Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-University, 81377 Munich, Germany
4
Department of Radiology, Ludwig-Maximilians-University Hospital, 80336 Munich, Germany
5
German Center for Diabetes Research, München-Neuherberg, 85764 Neuherberg, Germany
6
Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich, Ludwig-Maximilians-Universität, 80336 Munich, Germany
7
Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research, Munich-Neuherberg, 85764 Neuherberg, Germany
*
Author to whom correspondence should be addressed.
Tomography 2022, 8(2), 560-569; https://doi.org/10.3390/tomography8020046
Submission received: 19 January 2022 / Revised: 22 February 2022 / Accepted: 24 February 2022 / Published: 27 February 2022
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Abstract

Background: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. Methods: 203 study participants underwent whole-body MRI and pulmonary function tests as part of the KORA (Cooperative Health Research in the Augsburg Region) MRI study. Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were derived from the T1-Dixon sequence, and hepatic adipose tissue from the proton density fat fraction (PDFFhepatic). Associations between adipose tissue parameters and spirometric indices such as forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and Tiffeneau-index (FEV1/FVC) were examined using multivariate linear regression analysis excluding cofounding effects of other clinical parameters. Results: VAT (β = −0.13, p = 0.03) and SAT (β = −0.26, p < 0.001), but not PDFFhepatic were inversely associated with FEV1, while VAT (β = −0.27, p < 0.001), SAT (β = −0.41, p < 0.001), and PDFFhepatic (β = −0.17, p = 0.002) were inversely associated with FVC. PDFFhepatic was directly associated with the Tiffeneau index (β = 2.46, p < 0.001). Conclusions: In the adjusted linear regression model, VAT was inversely associated with all measured spirometric parameters, while PDFFhepatic revealed the strongest association with the Tiffeneau index. Non-invasive adipose tissue quantification measurements might serve as novel biomarkers for respiratory impairment.
Keywords: respiratory function tests; lung diseases; abdominal fat depots; hepatic fat content; magnetic resonance imaging respiratory function tests; lung diseases; abdominal fat depots; hepatic fat content; magnetic resonance imaging

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MDPI and ACS Style

Krüchten, R.v.; Rospleszcz, S.; Lorbeer, R.; Hasic, D.; Peters, A.; Bamberg, F.; Schulz, H.; Karrasch, S.; Schlett, C.L. Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment. Tomography 2022, 8, 560-569. https://doi.org/10.3390/tomography8020046

AMA Style

Krüchten Rv, Rospleszcz S, Lorbeer R, Hasic D, Peters A, Bamberg F, Schulz H, Karrasch S, Schlett CL. Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment. Tomography. 2022; 8(2):560-569. https://doi.org/10.3390/tomography8020046

Chicago/Turabian Style

Krüchten, Ricarda von, Susanne Rospleszcz, Roberto Lorbeer, Dunja Hasic, Annette Peters, Fabian Bamberg, Holger Schulz, Stefan Karrasch, and Christopher L. Schlett. 2022. "Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment" Tomography 8, no. 2: 560-569. https://doi.org/10.3390/tomography8020046

APA Style

Krüchten, R. v., Rospleszcz, S., Lorbeer, R., Hasic, D., Peters, A., Bamberg, F., Schulz, H., Karrasch, S., & Schlett, C. L. (2022). Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment. Tomography, 8(2), 560-569. https://doi.org/10.3390/tomography8020046

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