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Case Report

Imaging of Biliary Involvement in Sarcoidosis: Computed Tomography, Magnetic Resonance Cholangiopancreatography, and Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-Enhanced Magnetic Resonance Imaging Findings

1
Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
2
Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, IRCCS Sant’Orsola-Malpighi Hospital, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work and share first authorship.
These authors share senior authorship.
Academic Editors: Jan H. Ardenkjaer-Larsen and Emilio Quaia
Tomography 2021, 7(4), 783-791; https://doi.org/10.3390/tomography7040065
Received: 24 September 2021 / Revised: 8 November 2021 / Accepted: 9 November 2021 / Published: 13 November 2021
Sarcoidosis is a multisystem disease usually affecting the chest, hilar lymph nodes, and lungs, but can potentially involve any organ; therefore, its clinical presentation may vary. Hepatobiliary involvement is rare, and typically asymptomatic; however, it can lead to cirrhosis, and may require liver transplantation. In this report, we present a rare case of a patient affected by sarcoidosis with hepatobiliary involvement. He presented to our hospital complaining of dyspnea triggered by moderate efforts and oppressive thoracic discomfort. Chest X-ray showed multiple bilateral nodular opacities and enlargement of both hilar regions, confirmed by a subsequent total-body computed tomography scan and positron emission tomography, which also revealed cardiac, splenic, and hepatic involvement. Liver function was studied via gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging, and magnetic resonance cholangiopancreatography (MRCP) was also performed. The diagnosis of sarcoidosis was finally achieved via liver biopsy, revealing non-necrotizing granulomas in the periportal space. The patient was treated with prednisone per os, with regression of all lesions at all levels. Although other cases of biliary sarcoidosis have been described, this report provides a complete image set of Gd-EOB-DTPA-enhanced magnetic resonance and MRCP images that is lacking in the English literature, and which may be useful for diagnosis. View Full-Text
Keywords: sarcoidosis; biliary tract; cholangiopancreatography; magnetic resonance; multidetector computed tomography; positron emission tomography; liver diseases sarcoidosis; biliary tract; cholangiopancreatography; magnetic resonance; multidetector computed tomography; positron emission tomography; liver diseases
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MDPI and ACS Style

Renzulli, M.; Casavola, M.; Foà, A.; Pizzi, C.; Golfieri, R. Imaging of Biliary Involvement in Sarcoidosis: Computed Tomography, Magnetic Resonance Cholangiopancreatography, and Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-Enhanced Magnetic Resonance Imaging Findings. Tomography 2021, 7, 783-791. https://doi.org/10.3390/tomography7040065

AMA Style

Renzulli M, Casavola M, Foà A, Pizzi C, Golfieri R. Imaging of Biliary Involvement in Sarcoidosis: Computed Tomography, Magnetic Resonance Cholangiopancreatography, and Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-Enhanced Magnetic Resonance Imaging Findings. Tomography. 2021; 7(4):783-791. https://doi.org/10.3390/tomography7040065

Chicago/Turabian Style

Renzulli, Matteo, Mario Casavola, Alberto Foà, Carmine Pizzi, and Rita Golfieri. 2021. "Imaging of Biliary Involvement in Sarcoidosis: Computed Tomography, Magnetic Resonance Cholangiopancreatography, and Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-Enhanced Magnetic Resonance Imaging Findings" Tomography 7, no. 4: 783-791. https://doi.org/10.3390/tomography7040065

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