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Tomography
Volume 2
Issue 4
10.18383/j.tom.2016.00205
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Article

Evaluation of Cross-Calibrated 68Ge/68Ga Phantoms for Assessing PET/CT Measurement Bias in Oncology Imaging for Single- and Multicenter Trials

by
Darrin W. Byrd
1,
Robert K. Doot
2,
Keith C. Allberg
3,
Lawrence R. MacDonald
1,
Wendy A. McDougald
1,
Brian F. Elston
1,
Hannah M. Linden
4 and
Paul E. Kinahan
1,*
1
Department of Radiology, University of Washington, Seattle, WA, USA
2
Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
3
RadQual, LLC., Weare, NH, USA
4
Division of Medical Oncology, University of Washington, Seattle, WA, USA
*
Author to whom correspondence should be addressed.
Tomography 2016, 2(4), 353-360; https://doi.org/10.18383/j.tom.2016.00205
Submission received: 5 September 2016 / Revised: 11 October 2016 / Accepted: 9 November 2016 / Published: 1 December 2016
Versions Notes

Abstract

Quantitative PET imaging is an important tool for clinical trials evaluating the response of cancers to investigational therapies. The standardized uptake value, used as a quantitative imaging biomarker, is dependent on multiple parameters that may contribute bias and variability. The use of long-lived, sealed PET calibration phantoms offers the advantages of known radioactivity activity concentration and simpler use than aqueous phantoms. We evaluated scanner and dose calibrator sources from two batches of commercially available kits, together at a single site and distributed across a local multicenter PET imaging network. We found that radioactivity concentration was uniform within the phantoms. Within the regions of interest drawn in the phantom images, coefficients of variation of voxel values were less than 2%. Across phantoms, coefficients of variation for mean signal were close to 1%. Biases of the standardized uptake value estimated with the kits varied by site and were seen to change in time by approximately ±5%. We conclude that these biases cannot be assumed constant over time. The kits provide a robust method to monitor PET scanner and dose calibrator biases, and resulting biases in standardized uptake values.
Keywords: PET calibration; quantitative imaging; phantoms PET calibration; quantitative imaging; phantoms

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MDPI and ACS Style

Byrd, D.W.; Doot, R.K.; Allberg, K.C.; MacDonald, L.R.; McDougald, W.A.; Elston, B.F.; Linden, H.M.; Kinahan, P.E. Evaluation of Cross-Calibrated 68Ge/68Ga Phantoms for Assessing PET/CT Measurement Bias in Oncology Imaging for Single- and Multicenter Trials. Tomography 2016, 2, 353-360. https://doi.org/10.18383/j.tom.2016.00205

AMA Style

Byrd DW, Doot RK, Allberg KC, MacDonald LR, McDougald WA, Elston BF, Linden HM, Kinahan PE. Evaluation of Cross-Calibrated 68Ge/68Ga Phantoms for Assessing PET/CT Measurement Bias in Oncology Imaging for Single- and Multicenter Trials. Tomography. 2016; 2(4):353-360. https://doi.org/10.18383/j.tom.2016.00205

Chicago/Turabian Style

Byrd, Darrin W., Robert K. Doot, Keith C. Allberg, Lawrence R. MacDonald, Wendy A. McDougald, Brian F. Elston, Hannah M. Linden, and Paul E. Kinahan. 2016. "Evaluation of Cross-Calibrated 68Ge/68Ga Phantoms for Assessing PET/CT Measurement Bias in Oncology Imaging for Single- and Multicenter Trials" Tomography 2, no. 4: 353-360. https://doi.org/10.18383/j.tom.2016.00205

APA Style

Byrd, D. W., Doot, R. K., Allberg, K. C., MacDonald, L. R., McDougald, W. A., Elston, B. F., Linden, H. M., & Kinahan, P. E. (2016). Evaluation of Cross-Calibrated 68Ge/68Ga Phantoms for Assessing PET/CT Measurement Bias in Oncology Imaging for Single- and Multicenter Trials. Tomography, 2(4), 353-360. https://doi.org/10.18383/j.tom.2016.00205

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