Next Article in Journal
Promises and Presuppositions of Biomimicry
Next Article in Special Issue
Characterisation of the Interaction among Oil-In-Water Nanocapsules and Mucin
Previous Article in Journal
Surfactant Interactions with Protein-Coated Surfaces: Comparison between Colloidal and Macroscopically Flat Surfaces
Previous Article in Special Issue
Biomimetic Nanomembranes: An Overview
Review

Cationic Nanostructures for Vaccines Design

Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, SP, Brazil
*
Author to whom correspondence should be addressed.
Biomimetics 2020, 5(3), 32; https://doi.org/10.3390/biomimetics5030032
Received: 5 June 2020 / Revised: 2 July 2020 / Accepted: 3 July 2020 / Published: 7 July 2020
(This article belongs to the Special Issue Biomimetic Nanotechnology Vol. 2)
Subunit vaccines rely on adjuvants carrying one or a few molecular antigens from the pathogen in order to guarantee an improved immune response. However, to be effective, the vaccine formulation usually consists of several components: an antigen carrier, the antigen, a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a stimulator of humoral response such as an inflammasome activator. Most antigens are negatively charged and combine well with oppositely charged adjuvants. This explains the paramount importance of studying a variety of cationic supramolecular assemblies aiming at the optimal activity in vivo associated with adjuvant simplicity, positive charge, nanometric size, and colloidal stability. In this review, we discuss the use of several antigen/adjuvant cationic combinations. The discussion involves antigen assembled to (1) cationic lipids, (2) cationic polymers, (3) cationic lipid/polymer nanostructures, and (4) cationic polymer/biocompatible polymer nanostructures. Some of these cationic assemblies revealed good yet poorly explored perspectives as general adjuvants for vaccine design. View Full-Text
Keywords: cationic nanoparticles; dioctadecyldimethylammonium bromide; poly (acrylates); biomimetic lipid/polymer nanoparticles; cationic polymer /biocompatible polymer assemblies; cationic adjuvants; cationic lipids; polycation cationic nanoparticles; dioctadecyldimethylammonium bromide; poly (acrylates); biomimetic lipid/polymer nanoparticles; cationic polymer /biocompatible polymer assemblies; cationic adjuvants; cationic lipids; polycation
Show Figures

Figure 1

MDPI and ACS Style

Carmona-Ribeiro, A.M.; Pérez-Betancourt, Y. Cationic Nanostructures for Vaccines Design. Biomimetics 2020, 5, 32. https://doi.org/10.3390/biomimetics5030032

AMA Style

Carmona-Ribeiro AM, Pérez-Betancourt Y. Cationic Nanostructures for Vaccines Design. Biomimetics. 2020; 5(3):32. https://doi.org/10.3390/biomimetics5030032

Chicago/Turabian Style

Carmona-Ribeiro, Ana M., and Yunys Pérez-Betancourt. 2020. "Cationic Nanostructures for Vaccines Design" Biomimetics 5, no. 3: 32. https://doi.org/10.3390/biomimetics5030032

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop