Next Article in Journal
Real-Time Monitoring of Interactions between Solid-Supported Lipid Vesicle Layers and Short- and Medium-Chain Length Alcohols: Ethanol and 1-Pentanol
Next Article in Special Issue
Soft Robotics
Previous Article in Journal
Acknowledgement to Reviewers of Biomimetics in 2018
Previous Article in Special Issue
Biomechanics in Soft Mechanical Sensing: From Natural Case Studies to the Artificial World
Open AccessReview

Optimizing Epicardial Restraint and Reinforcement Following Myocardial Infarction: Moving Towards Localized, Biomimetic, and Multitherapeutic Options

1
Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA
2
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
3
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
*
Author to whom correspondence should be addressed.
Biomimetics 2019, 4(1), 7; https://doi.org/10.3390/biomimetics4010007
Received: 14 November 2018 / Revised: 31 December 2018 / Accepted: 9 January 2019 / Published: 17 January 2019
(This article belongs to the Special Issue Soft Robotics)
The mechanical reinforcement of the ventricular wall after a myocardial infarction has been shown to modulate and attenuate negative remodeling that can lead to heart failure. Strategies include wraps, meshes, cardiac patches, or fluid-filled bladders. Here, we review the literature describing these strategies in the two broad categories of global restraint and local reinforcement. We further subdivide the global restraint category into biventricular and univentricular support. We discuss efforts to optimize devices in each of these categories, particularly in the last five years. These include adding functionality, biomimicry, and adjustability. We also discuss computational models of these strategies, and how they can be used to predict the reduction of stresses in the heart muscle wall. We discuss the range of timing of intervention that has been reported. Finally, we give a perspective on how novel fabrication technologies, imaging techniques, and computational models could potentially enhance these therapeutic strategies. View Full-Text
Keywords: ventricular restraint; infarct reinforcement; biomimetics ventricular restraint; infarct reinforcement; biomimetics
Show Figures

Figure 1

MDPI and ACS Style

Varela, C.E.; Fan, Y.; Roche, E.T. Optimizing Epicardial Restraint and Reinforcement Following Myocardial Infarction: Moving Towards Localized, Biomimetic, and Multitherapeutic Options. Biomimetics 2019, 4, 7.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop