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Effects of Capsaicin on Biomimetic Membranes

School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan
Department of Food Science and Biotechnology, Faculty of Agriculture, Kagoshima University, 1-21-24, Korimoto, Kagoshima 890-0065, Japan
Author to whom correspondence should be addressed.
This article is an extended version of our paper presented at the Bioinspired Materials 2018 conference; paper No. 01.
Biomimetics 2019, 4(1), 17;
Received: 30 December 2018 / Revised: 3 February 2019 / Accepted: 5 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Selected Papers from Bioinspired Materials 2018)
Capsaicin is a natural compound that produces a warm sensation and is known for its remarkable medicinal properties. Understanding the interaction between capsaicin with lipid membranes is essential to clarify the molecular mechanisms behind its pharmacological and biological effects. In this study, we investigated the effect of capsaicin on thermoresponsiveness, fluidity, and phase separation of liposomal membranes. Liposomal membranes are a bioinspired technology that can be exploited to understand biological mechanisms. We have shown that by increasing thermo-induced membrane excess area, capsaicin promoted membrane fluctuation. The effect of capsaicin on membrane fluidity was dependent on lipid composition. Capsaicin increased fluidity of (1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) membranes, while it rigidified DOPC and cholesterol-based liposomes. In addition, capsaicin tended to decrease phase separation of heterogeneous liposomes, inducing homogeneity. We imagine this lipid re-organization to be associated with the physiological warming sensation upon consumption of capsaicin. Since capsaicin has been reported to have biological properties such as antimicrobial and as antiplatelet, the results will help unravel these biological properties. View Full-Text
Keywords: capsaicin; liposomes; thermoresponsiveness; membrane fluctuation; membrane excess area; membrane fluidity; phase separation capsaicin; liposomes; thermoresponsiveness; membrane fluctuation; membrane excess area; membrane fluidity; phase separation
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MDPI and ACS Style

Sharma, N.; Phan, H.T.T.; Yoda, T.; Shimokawa, N.; Vestergaard, M.C.; Takagi, M. Effects of Capsaicin on Biomimetic Membranes. Biomimetics 2019, 4, 17.

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