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Brief Report

Validation of Image Qualities of a Novel Four-Mice Bed PET System as an Oncological and Neurological Analysis Tool

1
Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea
2
Radiological and Medico-Oncological Sciences, University of science and technology (UST), Seoul 01812, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: George Kastis, Anastasios Gaitanis and Nicholas E. Protonotarios
J. Imaging 2021, 7(3), 43; https://doi.org/10.3390/jimaging7030043
Received: 5 February 2021 / Revised: 22 February 2021 / Accepted: 24 February 2021 / Published: 26 February 2021
(This article belongs to the Special Issue SPECT and PET Imaging of Small Animals)
Background: Micro-positron emission tomography (micro-PET), a small-animal dedicated PET system, is used in biomedical studies and has the quantitative imaging capabilities of radiotracers. A single-bed system, commonly used in micro-PET, is laborious to use in large-scale studies. Here, we evaluated the image qualities of a multi-bed system. Methods: Phantom imaging studies were performed to assess the recovery coefficients (RCs), uniformity, and spill-over ratios (SORs) in water- and air-filled chambers. 18F-FDG and 18F-FPEB PET images of xenograft and normal mice from the multi-bed and single-bed systems were compared. Results: For small diameters (< 3 mm), the RC values between the two systems differed significantly. However, for large diameters (> 4 mm), there were no differences in RC values between the two systems. Uniformity and SORs of both systems were within the tolerance limit of 15%. In the oncological study, the estimation of 18F-FDG uptake in the tumor was significantly lower in the multi-bed system than that in the single-bed system. However, 18F-FDG PET in xenograft mice with tumor size > 4 mm revealed the variation between subjects within the multi-bed system group to be less than 12%. In the neurological study, SUV for the multi-bed group was 25–26% lower than that for the single-bed group; however, inter-object variations within the multi-bed system were below 7%. Conclusions: Although the multi-bed system showed lower estimation of radiotracer uptake than that of the single-bed system, the inter-subject variations were within acceptable limits. Our results indicate that the multi-bed system can be used in oncological and neurological studies. View Full-Text
Keywords: positron emission tomography; multi-bed system; oncology; neurology positron emission tomography; multi-bed system; oncology; neurology
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MDPI and ACS Style

Kang, K.J.; Oh, S.J.; Nam, K.R.; Ahn, H.; Park, J.-A.; Lee, K.C.; Choi, J.Y. Validation of Image Qualities of a Novel Four-Mice Bed PET System as an Oncological and Neurological Analysis Tool. J. Imaging 2021, 7, 43. https://doi.org/10.3390/jimaging7030043

AMA Style

Kang KJ, Oh SJ, Nam KR, Ahn H, Park J-A, Lee KC, Choi JY. Validation of Image Qualities of a Novel Four-Mice Bed PET System as an Oncological and Neurological Analysis Tool. Journal of Imaging. 2021; 7(3):43. https://doi.org/10.3390/jimaging7030043

Chicago/Turabian Style

Kang, Kyung J., Se J. Oh, Kyung R. Nam, Heesu Ahn, Ji-Ae Park, Kyo C. Lee, and Jae Y. Choi 2021. "Validation of Image Qualities of a Novel Four-Mice Bed PET System as an Oncological and Neurological Analysis Tool" Journal of Imaging 7, no. 3: 43. https://doi.org/10.3390/jimaging7030043

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