Fluorescent Single-Core and Multi-Core Nanoprobes as Cell Trackers and Magnetic Nanoheaters
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Synthesis of MNPs
2.2.1. MNPs Prepared by Co-Precipitation Method
2.2.2. MNPs Prepared by Thermal Decomposition Method
2.2.3. MNPs Prepared by Microemulsion Method
2.2.4. MNPs Prepared by Solvothermal Method
2.2.5. MNPs Prepared by Stöber Method
2.3. Physicochemical Characterization
2.3.1. XRD Structural Characterization
2.3.2. Microscopy Morphological Characterization
2.3.3. Surface Chemistry Characterization
2.3.4. Hydrodynamic Particle Size and Zeta Potential Measurements
2.3.5. Compositional Characterization
2.3.6. Optical Properties
2.3.7. DC Magnetic Characterization
2.3.8. AC Magnetic Characterization
2.3.9. Magnetic Hyperthermia Characterization
3. Results and Discussion
3.1. X-ray Diffraction (XRD)
3.2. Transmission Electron Microscopy (TEM)
3.3. Optical Characterization of Fluorescent Single-Core MNPs
3.4. Magnetic Characterization
3.5. Magnetic Uptake and Cell Isolation with Fluorescence Single-Core MNPs
3.6. Heat Capacity of Multi-Core MNPs for Magnetic Hyperthermia and Nanowarming
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Core | Coating | Layer Content (wt %) | DH (nm) | DXRD (nm) | DTEM (nm) | PDI | Zeta Potential (mV) |
---|---|---|---|---|---|---|---|
Single-Core | PDA | 41.70 | 163.00 ± 131.50 | 12.27 | 14.90 | 0.445 | (+) 28.70 |
SiO2-RITC | 75.10 | 44.14 ± 19.73 | 9.28 | 22.50 | 0.195 | (−) 38.00 | |
SiO2-FITC | 82.60 | 142.20 ± 50.47 | 8.59 | 40.09 | 0.265 | (−) 45.50 | |
Multi-Core | CS | 34.10 | 201.20 ± 52.56 | 13.04 | 178.44 | 0.259 | (+) 12.00 |
Citrate | 7.10 | 339.80 ± 218.00 | 13.25 | 145.96 | 0.233 | (−) 50.50 | |
SiO2 | 78.1 | 215.50 ± 61.91 | 9.82 | 197.27 | 0.146 | (−) 45.93 |
Coating | MS (emug−1) | MR (emug−1) | HC (Oe) | TB (K) | |
---|---|---|---|---|---|
Single-Core | PDA | 65.38 | 5.74 | 51.7 | >350 |
SiO2-RITC | 71.44 | 0.65 | 3.53 | 96 | |
SiO2-FITC | 49.89 | 3.35 | 13.45 | 216 | |
Multi-Core | CS | 67.35 | 0.70 | 3.85 | >350 |
Citrate | 67.45 | 2.33 | 17.19 | >350 | |
SiO2 | 67.05 | 1.44 | 10.18 | ~350 |
Sample | HC-AC (kAm−1) | MR-AC (Am2kg−1) | MMax-AC (Am2kg−1) | Area (mJkg−1) | SARAC (Wg−1) | SARMH (Wg−1) | ΔT (°C) |
---|---|---|---|---|---|---|---|
Fe3O4@Cs | 1.4 | 3.1 | 36.9 | 181.4 | 63.2 | 19.56 | 16.54 |
Fe3O4@Citrate | 1.8 | 4.7 | 47.8 | 302.2 | 105.2 | 34.13 | 27.24 |
Fe3O4@SiO2 | 3.8 | 4.5 | 22.4 | 288.5 | 100.5 | 34.55 | 24.37 |
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García Acevedo, P.; González Gómez, M.A.; Arnosa Prieto, Á.; De Castro Alves, L.; Seco Gudiña, R.; Piñeiro, Y.; Rivas, J. Fluorescent Single-Core and Multi-Core Nanoprobes as Cell Trackers and Magnetic Nanoheaters. Magnetochemistry 2022, 8, 83. https://doi.org/10.3390/magnetochemistry8080083
García Acevedo P, González Gómez MA, Arnosa Prieto Á, De Castro Alves L, Seco Gudiña R, Piñeiro Y, Rivas J. Fluorescent Single-Core and Multi-Core Nanoprobes as Cell Trackers and Magnetic Nanoheaters. Magnetochemistry. 2022; 8(8):83. https://doi.org/10.3390/magnetochemistry8080083
Chicago/Turabian StyleGarcía Acevedo, Pelayo, Manuel A. González Gómez, Ángela Arnosa Prieto, Lisandra De Castro Alves, Román Seco Gudiña, Yolanda Piñeiro, and José Rivas. 2022. "Fluorescent Single-Core and Multi-Core Nanoprobes as Cell Trackers and Magnetic Nanoheaters" Magnetochemistry 8, no. 8: 83. https://doi.org/10.3390/magnetochemistry8080083