Next Article in Journal
Feature Papers in Magnetochemistry
Next Article in Special Issue
Magneto-Erythrocyte Membrane Vesicles’ Superior T2 MRI Contrast Agents to Magneto-Liposomes
Previous Article in Journal
Oscillatory Copper Deposition on Conical Iron Electrodes in a Nonuniform Magnetic Field
Article

Gd3+ Doped CoFe2O4 Nanoparticles for Targeted Drug Delivery and Magnetic Resonance Imaging

1
Polymer Research Lab, School of Chemical and Materials Engineering (SCME), National University of Science and Technology (NUST), Islamabad 44000, Pakistan
2
Department of Pharmacy, Quaid-i-Azam University (QAU), Islamabad 45320, Pakistan
3
Department of Cardiology, King Edward Medical University, Lahore 54000, Pakistan
4
Islamabad Diagnostic Center, Islamabad 44000, Pakistan
5
Institute of Analytical Sciences-UMR 5280 CNRS, Claude Bernard University Lyon 1, 69622 Villeurbanne, France
6
The Laboratory of Automatic Control, Chemical and Pharmaceutical Engineering-UMR 5007 CNRS, Claude Bernard University Lyon 1, 69622 Lyon, France
*
Author to whom correspondence should be addressed.
Academic Editor: Rumiana Tzoneva
Magnetochemistry 2021, 7(4), 47; https://doi.org/10.3390/magnetochemistry7040047
Received: 23 February 2021 / Revised: 24 March 2021 / Accepted: 26 March 2021 / Published: 30 March 2021
(This article belongs to the Special Issue Biomedical Application of Magnetic Nanoparticles in 2021)
Nanoparticles of CoGdxFe2 − xO4 (x = 0%, 25%, 50%) synthesized via sol–gel auto combustion technique and encapsulated within a polymer (Eudragit E100) shell containing curcumin by single emulsion solvent evaporation technique were formulated in this study. Testing of synthesized nanoparticles was carried out by using different characterization techniques, to investigate composition, crystallinity, size, morphology, surface charge, functional groups and magnetic properties of the samples. The increased hydrophilicity resulted in sustained drug release of 90.6% and 95% for E1(CoGd0.25Fe1.75O4) and E2(CoGd0.50Fe1.5O4), respectively, over a time span of 24 h. The relaxivities of the best-chosen samples were measured by using a 3T magnetic resonance imaging (MRI) machine, and a high r2/r1 ratio of 43.64 and 23.34 for composition E1(CoGd0.25Fe1.75O4) and E2(CoGd0.50Fe1.5O4) suggests their ability to work as a better T2 contrast agent. Thus, these novel synthesized nanostructures cannot only enable MRI diagnosis but also targeted drug delivery. View Full-Text
Keywords: cobalt ferrite nanoparticles; targeted drug delivery; in vitro diagnosis; magnetic resonance imaging; T2 weighted images cobalt ferrite nanoparticles; targeted drug delivery; in vitro diagnosis; magnetic resonance imaging; T2 weighted images
Show Figures

Figure 1

MDPI and ACS Style

Javed, F.; Abbas, M.A.; Asad, M.I.; Ahmed, N.; Naseer, N.; Saleem, H.; Errachid, A.; Lebaz, N.; Elaissari, A.; Ahmad, N.M. Gd3+ Doped CoFe2O4 Nanoparticles for Targeted Drug Delivery and Magnetic Resonance Imaging. Magnetochemistry 2021, 7, 47. https://doi.org/10.3390/magnetochemistry7040047

AMA Style

Javed F, Abbas MA, Asad MI, Ahmed N, Naseer N, Saleem H, Errachid A, Lebaz N, Elaissari A, Ahmad NM. Gd3+ Doped CoFe2O4 Nanoparticles for Targeted Drug Delivery and Magnetic Resonance Imaging. Magnetochemistry. 2021; 7(4):47. https://doi.org/10.3390/magnetochemistry7040047

Chicago/Turabian Style

Javed, Fatima, Muhammad A. Abbas, Muhammad I. Asad, Naveed Ahmed, Nauman Naseer, Hassan Saleem, Abdelhamid Errachid, Noureddine Lebaz, Abdelhamid Elaissari, and Nasir M. Ahmad. 2021. "Gd3+ Doped CoFe2O4 Nanoparticles for Targeted Drug Delivery and Magnetic Resonance Imaging" Magnetochemistry 7, no. 4: 47. https://doi.org/10.3390/magnetochemistry7040047

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop