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Magnetic Nanoparticle Systems for Nanomedicine—A Materials Science Perspective

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Romanian Academy–Timisoara Branch, Center for Fundamental and Advanced Technical Research, Laboratory of Magnetic Fluids, Mihai Viteazu Ave. 24, 300223 Timisoara, Romania
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Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Via Dodecaneso 31, 16146 Genova, Italy
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Istituto di Struttura della Materia-CNR, 00015 Monterotondo Scalo (RM), Italy
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Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Joliot-Curie Str. 6, 141980 Dubna, Russia
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BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain
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IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain
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Faculty of Physics, West University of Timisoara, V. Parvan Ave. 4, 300223 Timisoara, Romania
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Department of Physical Chemistry and Material Science, University of Szeged, 6720 Szeged, Hungary
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National Institute for Research and Development of Isotopic and Molecular Technologies (INCDTIM), Donat Str. 67-103, 400293 Cluj-Napoca, Romania
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Department of Food Engineering, Faculty of Engineering, University of Szeged, Moszkvai krt. 5-7, H-6725 Szeged, Hungary
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Authors to whom correspondence should be addressed.
Magnetochemistry 2020, 6(1), 2; https://doi.org/10.3390/magnetochemistry6010002
Received: 10 November 2019 / Revised: 16 December 2019 / Accepted: 19 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Magnetic Nanoparticles)
Iron oxide nanoparticles are the basic components of the most promising magneto-responsive systems for nanomedicine, ranging from drug delivery and imaging to hyperthermia cancer treatment, as well as to rapid point-of-care diagnostic systems with magnetic nanoparticles. Advanced synthesis procedures of single- and multi-core iron-oxide nanoparticles with high magnetic moment and well-defined size and shape, being designed to simultaneously fulfill multiple biomedical functionalities, have been thoroughly evaluated. The review summarizes recent results in manufacturing novel magnetic nanoparticle systems, as well as the use of proper characterization methods that are relevant to the magneto-responsive nature, size range, surface chemistry, structuring behavior, and exploitation conditions of magnetic nanosystems. These refer to particle size, size distribution and aggregation characteristics, zeta potential/surface charge, surface coating, functionalization and catalytic activity, morphology (shape, surface area, surface topology, crystallinity), solubility and stability (e.g., solubility in biological fluids, stability on storage), as well as to DC and AC magnetic properties, particle agglomerates formation, and flow behavior under applied magnetic field (magnetorheology). View Full-Text
Keywords: magnetic nanoparticle systems; bio-ferrofluids; nanomedicine; single core; multi-core; synthesis; functional coating; physical-chemical properties; structural characterization; magnetorheology magnetic nanoparticle systems; bio-ferrofluids; nanomedicine; single core; multi-core; synthesis; functional coating; physical-chemical properties; structural characterization; magnetorheology
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Socoliuc, V.; Peddis, D.; Petrenko, V.I.; Avdeev, M.V.; Susan-Resiga, D.; Szabó, T.; Turcu, R.; Tombácz, E.; Vékás, L. Magnetic Nanoparticle Systems for Nanomedicine—A Materials Science Perspective. Magnetochemistry 2020, 6, 2.

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