Application of Terpenoid Compounds in Food and Pharmaceutical Products
, Siqi Yuan 1,†, Lingshan Li 1, Jia Zheng 2, Dong Zhao 2, Chengjun Wang 1,2, Hong Wang 2, Xun Liu 1,* and Jun Liu 1,2,3,*Round 1
Reviewer 1 Report
1- page 1 line 25 : I suggest omit isoprene and bioactivity from keywords and add sesquiterpenes
2- References should be update
3- page 1line 10 :The sentence ; Terpenes are ompounds that includes monoterpenes, sesquiterpenes, diterpenes, and terpenes, where isoprene is the basic structural unit of multiples of hydrocarbons and their oxygenated instead of Terpene is a compound that includes monoterpenes, sesquiterpenes, diterpenes, and terpenes, where isoprene is the basic structural unit of multiples of hydrocarbons and their oxygenated derivatives.
4- page 1 line 13: omit word (from) from these sentence "Terpenes are often found in plants, especially in some Zingiberaceae or tulips, and they have been obtained by direct extraction, chemical synthesis, and from microorganisms"
5- Page 1 line 15,16: please add Terpenes in stead of terpene
6- page 4 line 150: what is the meaning of r-elemene?
7- page 5 line 167: the sentence ; From the above synthesis, γ-elemene had good biological activity------end of the sentence instead of From the above synthesis of γ-elemene γ-elemene had good biological activity------end of the sentence
8- page 6 line 198: the b-elemene instead of elemene
9- page 6 line 205 , 206 : omit --- and add all abbreviations between brackets such as MVA, DXP
10- page 10 line 330 : which type of elemene (b-elemene or g-elemene )
11- the conclusion in these review manuscript should be add
12- page 12 line 431: The discussions need improvement from the authors to explain the structure-activity relationship for all terpene components
Author Response
- page 1 line 25 : I suggest omit isoprene and bioactivity from keywords and add sesquiterpenes
Response: We have removed Isoprene and biological activity from the keywords, and added sesquiterpenes.
2- References should be update
The references have updated in the article.
- Mira, S. W.; Dominik, D. N. Antonio, D. D.; Ulrich, F. C. Distribution of Yeast Cells, Temperature, and Fermentation By-Products in White Wine Fermentations. American Journal of Enology and Viticulture. 2019, 70, 339-350.
- Wang, Q.; Liu, K. Y.; Liu, L. L.; Zheng, J.; Chen, T.; Chen. F.; Li, P. P.; Zhang, M.; Shen, X. J. Correlation Analysis Between Aroma Components and Microbial Communities in Wuliangye-flavor Raw Liquor Based on HS-SPME/LLME-GC–MS and PLFA. Food Research International. 2021, 140, 0963-9969.
- Zhang, X. Y.; Wang, C. C.; Wang, L. L.; Chen, S.; Yan, X. Optimization and validation of a head space solid-phase microextraction-arrow gas chromatography-mass spectrometry method using central composite design for determination of aroma compounds in Chinese liquor (Baijiu). Journal of Chromatography A. 2019, 10, 460-584.
- Wang, J.; Xu, C.; Chen, Y.; Shao, L.; Li, T.; Fan, X. X.; Yu, L. L.; Zhang, R. N.; Chen, B.; Chen, X. B. β-elemene Enhances the Antitumor Activity of Erlotinib by Inducing Apoptosis through AMPK and MAPK Pathways in TKI-resistant H1975 Lung Cancer Cells. Journal of Cancer. 2021, 12 ( 8 ), 2285-2294.
- Lin, H. M.; Chen, Y. Y.; Shi, A. H.; Zhu, G. Y. Phase 3 Randomized Low-Dose Paclitaxel Chemoradiotherapy Study for Locally Advanced Non-Small Cell Lung Cancer. Frontiers in Oncology.
- Zhu, L.; Chen, L. Progress in Research on Paclitaxel and Tumor Immunotherapy. Cellular & Molecular Biology Letters. 2019, 24, 40.
- Chen, H. Y.; Lei, J. Y.; Li, S. L.; Guo, L. Q.; Lin, J. F.; Wu, G. H.; Lu, J.; Ye, Z. W. Progress in Biological Activities and Biosynthesis of Edible Fungi Terpenoids. Critical reviews in food science and nutrition. 2022.
- X, S. L.; T, Z. Y.; W, Y. F. Recent Progress in the Antiviral Activity and Mechanism Study of Pentacyclic Triterpenoids and their Derivatives. Medicinal Research Reviews. 2018, 38( 3 ): 951-976.
- Yang, L. L.; Chen, F.; Gao, C.; Chen, J. B.; Li, J. Y.; Liu, S. Y.; Zhang, Y. Y.; Wang, Z. Y.; Qian, S. Design and Synthesis of Tricyclic Terpenoid Derivatives as Novel PTP1B Inhibitors with Improved Pharmacological Property and in Vivo Antihyperglycaemic Efficacy. Journal of Enzyme inhibition and Medicinal Chemistry. 2020, 1, 35, 152-164.
- Guimarães, A. C.; Meireles, L. M.; Lemos, M. F.; Guimarães, M. C. C.; Endringer, D. C.; Fronza, M.; Scherer, R. Antibacterial Activity of Terpenes and Terpenoids Present in Essential Oils. Molecules. 2019, 24, 2471.
- Liu, H. L,; Sun, B. G. Effect of Fermentation Processing on the Flavor of Baijiu. Journal of Agricultural and Food Chemistry. 2018, 66, 22, 5425–5432.
- Duan, M. Y.; Wang, F. Q.; Wu, G. P. Analysis of Flavor Characteristics of 4 Pepper Essential Oils. Food Science. 2022,43( 8 ), 213-219.
- Shen, H. S.; Development of Potato Instant Vermicelli Seasoning and Detection and Analysis of Flavor Substances. Journal of Northwest A&F University. 2019.
- Xiao, L.; Wang, P.; Han, Y. Effects of Zanthoxylum Bungeanum on Volatile Substances in Pepper PasteP. Chinese condiment. 2022, 47( 10 ), 161-165.
- Li, Y.; Zhao, H.Study on the Extraction and Separation Process of Peony Seasoning. Liquor Making, 2022. 49 ( 4 ), 138-143.
- Tomasino, E.; Bolman, S.The Potential Effect of β-ionone and β-damascenone on Sensory Perception of Pinot Noir Wine Aroma. Molecules. 2021, 26( 5 ), 1288.
3- page 1line 10 :The sentence ; Terpenes are compounds that includes monoterpenes, sesquiterpenes, diterpenes, and terpenes, where isoprene is the basic structural unit of multiples of hydrocarbons and their oxygenated instead of Terpene is a compound that includes monoterpenes, sesquiterpenes, diterpenes, and terpenes, where isoprene is the basic structural unit of multiples of hydrocarbons and their oxygenated derivatives.
Response: We replaced the sentence according to your suggestion.
- page 1 line 13: omit word (from) from these sentence "Terpenes are often found in plants, especially in some Zingiberaceae or tulips, and they have been obtained by direct extraction, chemical synthesis, and from microorganisms"
Response: We have omited the word (from) from these sentence.
- Page 1 line 15,16: please add terpenes in stead of terpene
Response: We revised it.
- page 4 line 150: what is the meaning of γ-elemene?
Response: In this article γ-elemene sesquiterpenes are natural sesquiterpenoids isolated from the volatile oil of turmeric rhizomes, have neuroprotective and anti-inflammatory properties.
- page 5 line 167: the sentence; From the above synthesis, γ-elemene had good biological activity------end of the sentence instead of From the above synthesis of γ-elemene γ-elemene had good biological activity------end of the sentence
Response: We deleted “of γ-elemene”, and use “from the above synthesis, γ-elemene had good biological activity” instead of from the above synthesis of γ-elemene γ-elemene had good biological activity in this sentence.
- page 6 line 198: the b-elemene instead of elemene
Response: We replaced b-elemene with “β-elemene”.
- page 6 line 205 , 206 : omit“---”and add all abbreviations between brackets such as MVA, DXP
Response:We have deleted “---” and added all abbreviations between brackets thoughout the manuscript.
- page 10 line 330 : which type of elemene (b-elemene or g-elemene )
Response: We sure it is β-elemene.
- the conclusion in these review manuscript should be add
Response: We have added some content to the conclusion. Please see the line 553-line 570 in the revised manuscript.
- page 12 line 431: The discussions need improvement from the authors to explain the structure-activity relationship for all terpene components
Response: We explained the structure-activity relationship for all terpene components in discussions. Please see the line 514-line 529 in the revised manuscript.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript is written well. However, more information needs to be added before the publication:
1) Authors need to include the biological properties such as antitumor activity, antibacterial activity, anti-Inflammatory activity, antiviral activities etc. They need to include the tabular form for more information.
2) A brief representation of terpenes and their medicinal uses should be added in the revised
3) Authors need to include the uses of terpenoids in flavor and fragrance agents.
Author Response
The manuscript is written well. However, more information needs to be added before the publication:
- Authors need to include the biological properties such as antitumor activity, antibacterial activity, anti-Inflammatory activity, antiviral activities etc. They need to include the tabular form for more information.
Response:We have added the biological properties in the sixth column of Table 2. Please see the line 340-line 341 in the revised manuscript.
- A brief representation of terpenes and their medicinal uses should be added in the revised
Response: In the manuscript, we summerized the application of terpenes in the pharmaceutical industry and added its medicinal uses in the revised version according to your suggestion: Please see the line 342-line 359 in the revised manuscript.
3) Authors need to include the uses of terpenoids in flavor and fragrance agents.
Response: We have added the uses of terpenoids in flavor and fragrance agents in the article.please see line 465-line 492 in the revised manuscript.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
non
