Near-Infrared, Light-Triggered, On-Demand Anti-Inflammatories and Antibiotics Release by Graphene Oxide/Elecrospun PCL Patch for Wound Healing
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Scaffold Preparation
2.3. Attenuated Total Reflectance Infrared Spectroscopy (FTIR-ATR)
2.4. X-ray Photoelectron Spectroscopy (XPS)
2.5. Scanning Electron Microscopy (SEM)
2.6. Water Uptake
2.7. Degradation Time
2.8. Water Contact Angle Measurement
2.9. Drug Loading and Drug Release Kinetics
2.10. Cell Adhesion Assay
2.11. Statistical Analysis
3. Results and Discussion
3.1. Surface Functionalization of PCL Patch with GO Via Nonthermal Low-Vacuum Nitrogen Plasma
3.2. GO Allows Water Uptake and Accelerates Degradation of the Scaffold
3.3. GO Coating Improves the Drug Loading and can Promote On-Demand Drug Release
3.4. GO Can Foster Wound Healing by Improving Cell Adhesion and Proliferation
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample | Ketoprofen a (mg/cm2) | Ibuprofen a (mg/cm2) | Vancomycin a (mg/cm2) |
---|---|---|---|
GO–PCL | 0.86 ± 0.01 | 5.85 ± 0.13 | 0.95 ± 0.05 |
Keplant® | 0.29 ± 0.02 | n.a. | n.a. |
Ibupas® | n.a. | 0.89 ± 0.08 | n.a. |
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Mauro, N.; Drago, S.E.; Cavallaro, G.; Giammona, G. Near-Infrared, Light-Triggered, On-Demand Anti-Inflammatories and Antibiotics Release by Graphene Oxide/Elecrospun PCL Patch for Wound Healing. C 2019, 5, 63. https://doi.org/10.3390/c5040063
Mauro N, Drago SE, Cavallaro G, Giammona G. Near-Infrared, Light-Triggered, On-Demand Anti-Inflammatories and Antibiotics Release by Graphene Oxide/Elecrospun PCL Patch for Wound Healing. C. 2019; 5(4):63. https://doi.org/10.3390/c5040063
Chicago/Turabian StyleMauro, Nicolò, Salvatore Emanuele Drago, Gennara Cavallaro, and Gaetano Giammona. 2019. "Near-Infrared, Light-Triggered, On-Demand Anti-Inflammatories and Antibiotics Release by Graphene Oxide/Elecrospun PCL Patch for Wound Healing" C 5, no. 4: 63. https://doi.org/10.3390/c5040063