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Carbon-Based Magnetic Nanocarrier for Controlled Drug Release: A Green Synthesis Approach

Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
Department of Chemical Engineering, Universidade Tecnológica Federal do Paraná, Av. Monteiro Lobato, s/n–Jardim Carvalho, Ponta Grossa, PR 84016-210, Brasil
Laboratory of Separation and Reaction Engineering—Laboratory of Catalysis and Materials (LSRE-LCM), Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040-01 Košice, Slovak Republic
Author to whom correspondence should be addressed.
Received: 15 November 2018 / Revised: 15 December 2018 / Accepted: 22 December 2018 / Published: 28 December 2018
(This article belongs to the Special Issue Biomedical Applications of Carbon Materials)
PDF [4391 KB, uploaded 28 December 2018]


In this study, hydrophilic magnetic nanoparticles were synthesized by green routes using a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were coated with carbon-based shell for drug delivery application. The nanocomposites were further chemically functionalized with nitric acid and, sequentially, with Pluronic® F68 (CMNPs-plur) to enhance their colloidal stability. The resulting material was dispersed in phosphate buffer solution at pH 7.4 to study the Doxorubicin loading. After shaking for 48 h, 99.13% of the drug was loaded by the nanocomposites. Subsequently, the drug release was studied in different working phosphate buffer solutions (i.e., PB pH 4.5, pH 6.0 and pH 7.4) to determine the efficiency of the synthesized material for drug delivery as pH-dependent drug nanocarrier. The results have shown a drug release quantity 18% higher in mimicking tumor environment than in the physiological one. Therefore, this study demonstrates the ability of CMNPs-plur to release a drug with pH dependence, which could be used in the future for the treatment of cancer "in situ" by means of controlled drug release. View Full-Text
Keywords: green routes; magnetic nanoparticles; drug delivery; cancer therapy; doxorubicin green routes; magnetic nanoparticles; drug delivery; cancer therapy; doxorubicin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Oliveira, J.R.P.; Rodrigues, R.O.; Barros, L.; Ferreira, I.C.F.R.; Marchesi, L.F.; Koneracka, M.; Jurikova, A.; Zavisova, V.; Gomes, H.T. Carbon-Based Magnetic Nanocarrier for Controlled Drug Release: A Green Synthesis Approach. C 2019, 5, 1.

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