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Volume 6
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10.3390/ncrna6030038
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Review

Non-Coding RNAs: Strategy for Viruses’ Offensive

by
Alessia Gallo
1,*,
Matteo Bulati
1,
Vitale Miceli
1,
Nicola Amodio
2 and
Pier Giulio Conaldi
1,3
1
Department of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Via E.Tricomi 5, 90127 Palermo, Italy
2
Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
3
UPMC Italy (University of Pittsburgh Medical Center Italy), Discesa dei Giudici 4, 90133 Palermo, Italy
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2020, 6(3), 38; https://doi.org/10.3390/ncrna6030038
Submission received: 7 August 2020 / Revised: 1 September 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
(This article belongs to the Section Detection and Biomarkers of Non-Coding RNA)
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Abstract

The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle.
Keywords: immune evasion; miRNA mimicry; viral circRNA; viral non-coding RNA immune evasion; miRNA mimicry; viral circRNA; viral non-coding RNA

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MDPI and ACS Style

Gallo, A.; Bulati, M.; Miceli, V.; Amodio, N.; Conaldi, P.G. Non-Coding RNAs: Strategy for Viruses’ Offensive. Non-Coding RNA 2020, 6, 38. https://doi.org/10.3390/ncrna6030038

AMA Style

Gallo A, Bulati M, Miceli V, Amodio N, Conaldi PG. Non-Coding RNAs: Strategy for Viruses’ Offensive. Non-Coding RNA. 2020; 6(3):38. https://doi.org/10.3390/ncrna6030038

Chicago/Turabian Style

Gallo, Alessia, Matteo Bulati, Vitale Miceli, Nicola Amodio, and Pier Giulio Conaldi. 2020. "Non-Coding RNAs: Strategy for Viruses’ Offensive" Non-Coding RNA 6, no. 3: 38. https://doi.org/10.3390/ncrna6030038

APA Style

Gallo, A., Bulati, M., Miceli, V., Amodio, N., & Conaldi, P. G. (2020). Non-Coding RNAs: Strategy for Viruses’ Offensive. Non-Coding RNA, 6(3), 38. https://doi.org/10.3390/ncrna6030038

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