Next Article in Journal
Non-Coding RNAs: Strategy for Viruses’ Offensive
Next Article in Special Issue
Involvement of Long Non-Coding RNAs (lncRNAs) in Tumor Angiogenesis
Previous Article in Journal / Special Issue
Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time
Open AccessReview

Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology

1
IRCSS Istituto Ortopedico Rizzoli, SC Scienze e Tecnologie Chirurgiche–SS Piattaforma Scienze Omiche per Ortopedia Personalizzata, 40136 Bologna, Italy
2
Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy
3
IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Research Department, 90127 Palermo, Italy
4
Department of Oncology and Hemato-oncology, University of Milan, 20122 Milan, Italy
5
Hematology, Fondazione Cà Granda IRCCS Policlinico, 20122 Milan, Italy
6
Institute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), 90146 Palermo, Italy
7
Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
*
Authors to whom correspondence should be addressed.
These authors equally contributed to this work.
Non-Coding RNA 2020, 6(3), 37; https://doi.org/10.3390/ncrna6030037
Received: 10 August 2020 / Revised: 27 August 2020 / Accepted: 8 September 2020 / Published: 9 September 2020
(This article belongs to the Collection Feature Papers in Non-coding RNA)
Bone remodeling is uncoupled in the multiple myeloma (MM) bone marrow niche, resulting in enhanced osteoclastogenesis responsible of MM-related bone disease (MMBD). Several studies have disclosed the mechanisms underlying increased osteoclast formation and activity triggered by the various cellular components of the MM bone marrow microenvironment, leading to the identification of novel targets for therapeutic intervention. In this regard, recent attention has been given to non-coding RNA (ncRNA) molecules, that finely tune gene expression programs involved in bone homeostasis both in physiological and pathological settings. In this review, we will analyze major signaling pathways involved in MMBD pathophysiology, and report emerging evidence of their regulation by different classes of ncRNAs. View Full-Text
Keywords: bone disease; long non-coding RNA; miRNA; multiple myeloma; non-coding RNA; tumor microenvironment bone disease; long non-coding RNA; miRNA; multiple myeloma; non-coding RNA; tumor microenvironment
Show Figures

Figure 1

MDPI and ACS Style

Raimondi, L.; De Luca, A.; Giavaresi, G.; Raimondo, S.; Gallo, A.; Taiana, E.; Alessandro, R.; Rossi, M.; Neri, A.; Viglietto, G.; Amodio, N. Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology. Non-Coding RNA 2020, 6, 37. https://doi.org/10.3390/ncrna6030037

AMA Style

Raimondi L, De Luca A, Giavaresi G, Raimondo S, Gallo A, Taiana E, Alessandro R, Rossi M, Neri A, Viglietto G, Amodio N. Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology. Non-Coding RNA. 2020; 6(3):37. https://doi.org/10.3390/ncrna6030037

Chicago/Turabian Style

Raimondi, Lavinia; De Luca, Angela; Giavaresi, Gianluca; Raimondo, Stefania; Gallo, Alessia; Taiana, Elisa; Alessandro, Riccardo; Rossi, Marco; Neri, Antonino; Viglietto, Giuseppe; Amodio, Nicola. 2020. "Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology" Non-Coding RNA 6, no. 3: 37. https://doi.org/10.3390/ncrna6030037

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop