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Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time

Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, NY 11794-5222, USA
Non-Coding RNA 2020, 6(3), 36; https://doi.org/10.3390/ncrna6030036
Received: 16 July 2020 / Revised: 17 August 2020 / Accepted: 1 September 2020 / Published: 3 September 2020
(This article belongs to the Collection Feature Papers in Non-coding RNA)
A small phylogenetically conserved sequence of 11,231 bp, termed FAM247, is repeated in human chromosome 22 by segmental duplications. This sequence forms part of diverse genes that span evolutionary time, the protein genes being the earliest as they are present in zebrafish and/or mice genomes, and the long noncoding RNA genes and pseudogenes the most recent as they appear to be present only in the human genome. We propose that the conserved sequence provides a nucleation site for new gene development at evolutionarily conserved chromosomal loci where the FAM247 sequences reside. The FAM247 sequence also carries information in its open reading frames that provides protein exon amino acid sequences; one exon plays an integral role in immune system regulation, specifically, the function of ubiquitin-specific protease (USP18) in the regulation of interferon. An analysis of this multifaceted sequence and the genesis of genes that contain it is presented. View Full-Text
Keywords: de novo gene birth; gene evolution; protogene; long noncoding RNA genes; pseudogenes; USP18; GGT5; Alu sequences de novo gene birth; gene evolution; protogene; long noncoding RNA genes; pseudogenes; USP18; GGT5; Alu sequences
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MDPI and ACS Style

Delihas, N. Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time. Non-Coding RNA 2020, 6, 36. https://doi.org/10.3390/ncrna6030036

AMA Style

Delihas N. Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time. Non-Coding RNA. 2020; 6(3):36. https://doi.org/10.3390/ncrna6030036

Chicago/Turabian Style

Delihas, Nicholas. 2020. "Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time" Non-Coding RNA 6, no. 3: 36. https://doi.org/10.3390/ncrna6030036

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