Long Non-Coding RNA Modulation of VEGF-A during Hypoxia
AbstractThe role and function of long non-coding RNAs (lncRNAs) in modulating gene expression is becoming apparent. Vascular endothelial growth factor A (VEGF-A) is a key regulator of blood vessel formation and maintenance making it a promising therapeutic target for activation in ischemic diseases. In this study, we uncover a functional role for two antisense VEGF-A lncRNAs, RP1-261G23.7 and EST AV731492, in transcriptional regulation of VEGF-A during hypoxia. We find here that both lncRNAs are polyadenylated, concordantly upregulated with VEGF-A, localize to the VEGF-A promoter and upstream elements in a hypoxia dependent manner either as a single-stranded RNA or DNA bound RNA, and are associated with enhancer marks H3K27ac and H3K9ac. Collectively, these data suggest that VEGF-A antisense lncRNAs, RP1-261G23.7 and EST AV731492, function as VEGF-A promoter enhancer-like elements, possibly by acting as a local scaffolding for proteins and also small RNAs to tether. View Full-Text
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Nieminen, T.; Scott, T.A.; Lin, F.-M.; Chen, Z.; Yla-Herttuala, S.; Morris, K.V. Long Non-Coding RNA Modulation of VEGF-A during Hypoxia. Non-Coding RNA 2018, 4, 34.
Nieminen T, Scott TA, Lin F-M, Chen Z, Yla-Herttuala S, Morris KV. Long Non-Coding RNA Modulation of VEGF-A during Hypoxia. Non-Coding RNA. 2018; 4(4):34.Chicago/Turabian Style
Nieminen, Tiina; Scott, Tristan A.; Lin, Feng-Mao; Chen, Zhen; Yla-Herttuala, Seppo; Morris, Kevin V. 2018. "Long Non-Coding RNA Modulation of VEGF-A during Hypoxia." Non-Coding RNA 4, no. 4: 34.
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