MicroRNA-Attenuated Virus Vaccines
AbstractLive-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses. However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines. The use of host-derived microRNAs (miRNAs) to attenuate viruses has been accomplished in an array of biological contexts. The broad assortment of effective tissue- and species-specific miRNAs, and the ability to target a virus with multiple miRNAs, allow for targeting to be tailored to the virus of interest. While escape is always a concern, effective strategies have been developed to improve the safety and stability of miRNA-attenuated viruses. In this review, we discuss the various approaches that have been used to engineer miRNA-attenuated viruses, the steps that have been taken to improve their safety, and the potential use of these viruses as vaccines. View Full-Text
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Fay, E.J.; Langlois, R.A. MicroRNA-Attenuated Virus Vaccines. Non-Coding RNA 2018, 4, 25.
Fay EJ, Langlois RA. MicroRNA-Attenuated Virus Vaccines. Non-Coding RNA. 2018; 4(4):25.Chicago/Turabian Style
Fay, Elizabeth J.; Langlois, Ryan A. 2018. "MicroRNA-Attenuated Virus Vaccines." Non-Coding RNA 4, no. 4: 25.
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