Hydrogels for Salivary Gland Tissue Engineering
Abstract
:1. Introduction
2. Tuning Ideal Hydrogel Properties for SG Tissue Engineering
2.1. Hydrogel Biocompatibility
2.2. Presence of Cell Binding Motifs
2.3. Hydrogel Stiffness
2.4. Hydrogel Pore Size
2.5. Viscoelasticity and Hydrogel Architecture
3. Advances in Hydrogel Systems for Building an Artificial SG
3.1. Naturally Derived Hydrogels
3.2. Synthetic Hydrogels
4. Conclusions and Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
Abbreviations
2D | Two-dimensional |
2.5D | Two-point-five-dimensional |
3D | Three-dimensional |
Akt | Protein kinase B (PKB) |
APC | Adenomatous polyposis coli |
AQP-5 | Aquaporin 5 |
BM | Basement membrane proteins |
CD44 | Cluster of Differentiation 44 |
DGEA | Aspartic acid-glycine-glutamic acid-alanine |
ECM | Extracellular matrix |
EDTA | Ethylenediaminetetraacetic acid |
EW | Egg White |
EYP | Egg Yolk Plasma |
FA | Focal adhesion |
FAKs | Focal adhesion kinases |
GelMA | Gelatin-methacrylamide |
GSK3β | Glycogen synthase kinase 3 beta |
HA | Hyaluronic acid |
Kit | Tyrosine-protein kinase (CD117) |
Lasts 1/2 | Large tumor suppressor 1 and 2 |
Mist-1 | Muscle, intestine and stomach expression 1 |
MLCK | Myosin light-chain kinase |
Mst 1/2 | Mammalian sterile 20-like kinase 1 and 2 |
MW | Molecular weight |
NF2 | Neurofibromatosis type 2 |
NS-SV-AC | Normal human SG-simian virus 40-acinar cells |
PCL | Polycaprolactone |
PEG | Polyethelene glycol |
PG | Parotid gland |
PGA | Polyglycolic acid |
PI3K | Phosphatidylinositol-3-kinase |
PLLA | Poly-l-lactic acid |
PLGA | Poly-l-lactic-co-glycolic acid |
RGD | Arginine-glycine-aspartic acid |
RhoA | Transforming protein RhoA |
ROCK | Rho kinases |
SGs | Salivary glands |
SLG | Sublingual gland |
SMG | Submandibular gland |
SRC | Proto-oncogene tyrosine-protein kinase |
TAZ | Transcriptional co-activator with PDZ-binding motif |
YAP | Yes Associated Protein |
YIGSR | Tyrosine-isoleucine-glycine-serine-arginine |
ZO-1 | Zonula occludens-1 |
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Pillai, S.; Munguia-Lopez, J.G.; Tran, S.D. Hydrogels for Salivary Gland Tissue Engineering. Gels 2022, 8, 730. https://doi.org/10.3390/gels8110730
Pillai S, Munguia-Lopez JG, Tran SD. Hydrogels for Salivary Gland Tissue Engineering. Gels. 2022; 8(11):730. https://doi.org/10.3390/gels8110730
Chicago/Turabian StylePillai, Sangeeth, Jose G. Munguia-Lopez, and Simon D. Tran. 2022. "Hydrogels for Salivary Gland Tissue Engineering" Gels 8, no. 11: 730. https://doi.org/10.3390/gels8110730