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Article

Gelating Abilities of Two-Component System of Catecholic Derivatives and a Boronic Acid

by
Akihiko Tsuge
*,
Ryota Kamoto
,
Daisuke Yakeya
and
Koji Araki
Department of Applied Chemistry, Kyushu Institute of Technology, Kitakyushu 804-8550, Japan
*
Author to whom correspondence should be addressed.
Gels 2019, 5(4), 45; https://doi.org/10.3390/gels5040045
Submission received: 19 July 2019 / Revised: 20 August 2019 / Accepted: 18 October 2019 / Published: 22 October 2019
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Abstract

:
In the last two decades, various kinds of the low-molecular-weight organogelators (LMOGs) have been investigated in terms of technological applications in various fields as well as their fundamental scientific properties. The process of gelation is generally considered to arise from immobilization of the solvents in the three-dimensional networks formed by the assembly of gelator molecules through weak intermolecular noncovalent interactions. From these points of view a huge number of organogelators have been developed so far. In the course of our research on LMOGs we have noticed a mixture of two gelators could show a different trend in gelation compared to the single gelator. It is well known that the catecholic moiety easily forms cyclic boronate esters with the boronic acid. Thus, we have investigated the two-component system based on cyclic boronate esters formed by the catechols and a boronic acid in terms of the control of gelation capability. Basic gelation properties of the constituent catecholic gelators have also been clarified. The catecholic gelators with the amide unit form no gel by addition of the boronic acid. In contrast, the catecholic gelators with the glutamic acid moiety improve their gelation abilities by mixing with the boronic acid. Furthermore, the gelation ability of the catecholic gelators having the urea unit is maintained after addition of the boronic acid. It has been found that gelation abilities of the catecholic gelators are highly affected by addition of the boronic acid. In terms of practical applications some gels can be obtained by on-site mixture of two kinds of solutions.

Graphical Abstract

1. Introduction

Self-assembly plays an important role in the creation of attractive functional soft materials [1]. Supramolecular gels formed by self-assembly of the low-molecular-weight organogelators (LMOGs) [2,3,4,5,6,7,8,9,10,11,12,13,14,15] are an emerging field because they are not only related to fundamental scientific interests, but also applied to a practical usage in various areas.
Although it seems difficult to predict the whole structural requirements for molecules to show gelation properties in organic solvents, the information obtained from a wide variety of organogelators helps to rationalize what kinds of chemical structures are necessary for building organogels. These required structures are closely related to non-covalent bonding such as hydrogen bonds, electrostatic attraction, hydrophobic interaction, and π–π interactions. In the last few decades a large number of organogelators have been discussed in terms of structural features, effects of noncovalent interactions, properties of gels, and aspects of their functions [16,17,18,19,20,21,22]. From this point of view we have developed organogelators based on the cyclophane skeletons [23,24], the europium complex [25], coumarin structure [26], and ferrocene unit [27].
When considering the structural unit for building a gelator molecule, the catechol group has to be attractive because non-covalent bonding, such as hydrophobic interaction, electrostatic interaction, hydrogen bonds, π–π interactions, and metal-ligand coordination bonding, can be expected, and is also well known to exhibit adhesive characteristics on a variety of surfaces [28,29,30]. Furthermore, a diol and boronic acid complex [31], which is easily formed from each component, is known as a useful tool for the construction of organized architectures in supramolecular chemistry [32,33]. This system based on a dynamic covalent bonding might be advantageous for creation of chemical stimuli-responsive soft materials [34,35,36]. In terms of gel systems using this diol/boronic acid complex, the gel materials responding to some sugars such as a glucose have been reported [37,38]. This complex has also been applied to polymer gels [39], star-shaped gels [40], and bola-shaped gels [41].
Thus, from these points of view it is expected that the gelators containing the catechol unit could provide a unique system.
Here we have designed some catecholic gelators which have the amide unit or the urea unit as the connection with the long alkyl chain and examined their preliminary gelating properties. Successively, the two-component system based on cyclic boronate esters formed by the catechols and the boronic acid has also been investigated in terms of formation of gels.

2. Results and Discussion

We have synthesized three kinds of the catecholic derivatives (2, 4, 6) as shown in Scheme 1. The catecholic derivatives 2a–d were obtained by treating 1a–d prepared from 3,4-dimethoxybenzoyl chloride and the corresponding alkylamines with BBr3 in the yields of 44–74%. The reaction of 3,4-dimethoxybenzoic acid and the corresponding alkylamines in the presence of diphenylphosphoryl azide (DPPA) in DME gave the urea compounds 3a–d, followed by demethylation with BBr3 to afford the desired catecholic derivatives 4a–d in the yields of 74–94%. The compounds 5a–d were synthesized by condensation of the corresponding glutamic acid derivatives and 3,4-dimethoxybenzoic acid using diethyl cyanophosphonate (DECP). By treating 5a–d with BBr3 the catecholic derivatives having the glutamic acid moiety 6a–d were obtained in the yields of 50–76%. The referential compounds 7 and 8 were also prepared by the similar method as described above. The boronic acid carrying the long alkyl chain 9 was obtained by the condensation of 4-carboxyphenylboronic acid and the corresponding alkylamine under DECP in the yields of 74% as shown in Scheme 1.
We have examined various kinds of solvents for the gelation behaviors of the catecholic derivatives prepared here. The catecholic derivatives 2a–d show very good solubility against polar solvents such as DMSO, DMF, EtOH, and MeOH as in Table 1, resulting in no gelation. The gelation properties of 2a–d in other solvents are also summarized in Table 1. Formation of gel in toluene and benzene was confirmed for 2c and 2d. It was found out that the compound 2d having the longer alkyl chain gelated chloroform.
The gelation properties of the catecholic derivatives 4a–d were also examined in various solvents as summarized in Table 1. 4b,c show a different trend of gelation between toluene and benzene. Although a stable gel from 4b and 4c in toluene was observed, a partial gel was only formed in benzene. The partial gel means that the gel once formed on cooling tends to collapse after a while. Chloroform can be effectively gelated by 4d. The only compound that can gelate EtOH is 4d, regardless of excellent solubility of 4a–d in alcohols. The compound 4d with the long alkyl chain tends to form the gel in DMF and DMSO. The optical image and SEM analysis of the gel from 4d in toluene are shown in Figure 1a as an example. A developed network of elongated fibers was observed.
The catecholic derivatives 6a–d exhibit a poor solubility in hexane and cyclohexane, and an excellent solubility in DMF and DMSO. Some gel formations were confirmed as shown in Table 2. Compound 6d is able to gelate toluene and benzene. Interestingly, 6c tends to build a partial gel in these solvents. As an example the optical image and SEM analysis of the gel from 6d in DMSO are shown in Figure 1b. Relatively thick fibers were observed.
In order to know the effect of the hydroxyl group we examined the gelation properties of the phenol derivative 7 as well as the compound 8. The results are also summarized in Table 2.
Although no gelation from 7 in any solvents examined was observed, the compound 8 carrying three hydroxy groups clearly shows better gelation abilities compared to 2c. The minimum concentration of 8 for gelation in toluene and benzene is about ten times lower than that of 2c. This result strongly indicates that the hydroxy group plays a crucial role in gel formation.
Although the boronic acid 9 tends to dissolve in EtOH, MeOH, DMF, and DMSO, its precipitate was produced in solvents such as benzene, toluene, and chloroform. Thus, the boronic acid 9 itself showed no gelation in organic solvents examined. We carried out the gelation test for the 1:1 mixture of catecholic compounds and 9 as summarized in Table 3. The 1:1 mixture of 2c and 9 in toluene and benzene shows no gelation despite several trials. The similar results were obtained for the mixture of 2d. Although the gel is formed by 2d in chloroform, the 1:1 mixture with 9 cannot produce such a gel. This decline of the ability in gelation can be ascribed to the loss of the hydroxy groups due to formation of a boronate ester.
In contrast it has been found out that 4b–d maintain their ability for gelation in toluene and chloroform even after mixing with 9 as shown in Table 3. It is interesting that the stable gels of 4b and 4c were formed in benzene by mixing with 9 because they form the partial gels without 9. In this case the urea group might compensate for the loss of hydrogen bonding based on the hydroxy groups. We have examined thermal stability of the gels from 4d and 4d/9 in chloroform. The gels from both of them collapsed at the same temperature (ca. 45 °C).
On the other hand the improvement of gelation ability for the compounds 6 can be also observed when they are mixed with 9 (Table 3). Although no change for gelation properties of 6b was observed, some improvements in gelation were confirmed for 6c and 6d. Compound 6c itself exhibited a partial gel in benzene and toluene, however, the stable gel was formed by the 1:1 mixture with 9. Furthermore the mixture of 6d also shows formation of gel in chloroform despite no gelation by 6d itself.
Figure 2 shows the optical image and SEM analysis of the gel from the mixture of 6d and 9 in chloroform. A clear gel was obtained and a developed network was observed. The reason for this enhancement of gelation is still unclear, however, it is expected that three long alkyl chains in the molecule could contribute to an effective molecular assembly.

3. Conclusions

We have prepared organogelators based on the catechol unit having the amide, the urea, and glutamic acid moieties. We have clarified their basic properties of gelation in organic solvents. It has also been found that the gelation abilities of these catecholic gelators are highly affected by the addition of a boronic acid. The catecholic gelators with the amide unit lose their gelation abilities by the addition of a boronic acid. No effect on gelation properties was observed for the catecholic gelators with the urea unit. In contrast it should be noted that the catecholic gelators with the glutamic acid moiety improve their gelation abilities by mixing with the boronic acid. These phenomena might be ascribed to formation of the boronic ester. Further research according to this concept is currently underway in our laboratory. It should be noted that the system described here has an advantage from the viewpoint of practical usage because the gel can be formed on-site by mixing up two kinds of solutions containing the catecholic derivative and the boronic acid, respectively.

4. Materials and Methods

4.1. General

All chemicals were purchased from commercial suppliers and used without further purification. Melting points were obtained by a Yanagimoto MP-52 melting point apparatus (AE-MIC Trading, Kyoto, Japan). Nuclear magnetic resonance (NMR) spectra were measured on a Bruker ADVANCE HD 500 spectrometer (Billerica, MA, USA) with Me4Si as the internal reference. J values are given in Hz. Mass spectra were recorded by using a JEOL JMS-SX102A spectrometer (JEOL, Tokyo, Japan). Elemental analysis was carried out with Yanaco MT-6 CHN recorder (Yanaco New Science Inc., Kyoto, Japan).

4.2. Typical Procedure for Syntheses of 2a–d

After a solution of 3,4-dimethoxybenzoyl chloride (4.40 g, 22 mmol) and hexylamine (2.92 mL, 22 mmol) together with triethylamine (3.20 mL, 23 mmol) in chloroform (50 mL) was stirred for 2 h at room temperature, the reaction mixture was washed with brine and water, then dried over sodium sulfate. The chloroform solution was evaporated under reduced pressure to leave a residue that was recrystallized from hexane to give 1a (4.90 g, 84%). To a stirred solution of 1a (2.01 g, 7.6 mmol) in dichloromethane (40 mL) at 0 °C a solution of BBr3 (4.72 g, 18.8 mmol) in dichloromethane (40 mL) was added dropwise. After the reaction mixture was stirred for 13 h at room temperature, it was poured into ice-water. The mixture was stirred for a further 2 h at room temperature and extracted with ethyl acetate. The extract was washed with water, dried over sodium sulfate, and evaporated under reduced pressure to afford a residue which, on recrystallization from ethyl acetate and hexane, gave 2a as white powder (1.18 g, 65%).
Compound2a: Yield 65%; white powder; mp 152–154 °C (EtOAc/hexane); IR νmax (KBr)/cm−1: 3328, 3045, 2960, 1642, 1584, 1495, 1425, 1364, 1226, 1050, 1022, 805, 685; 1H NMR (500 MHz; DMSO-d6) δ 0.86 (3H, t, J = 6.8 CH3), 1.26–1.32 (6H, m, CH2), 1.46–1.50 (2H, m, CH2), 3.18–3.20 (2H, m, CH2NH), 6.73 (1H, d, J = 7.0 ArH), 7.16 (1H, dd, J = 1.6, 7.0 ArH), 7.26 (1H, d, J = 1.6 ArH), 8.10 (1H, s, NH), 9.05 (1H, s, ArOH), 9.40 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.4, 27.0, 31.8, 32.2, 68.4, 118.2, 120.2, 128.4, 132.8, 151.6, 152.4, 170.6; fast atom bombardment (FAB) MS m/z 237 (M+); Anal. Found: C, 65.64; H, 8.33; N, 5.75%, Calc. for C13H19NO3: C, 65.79; H, 8.09; N, 5.90%.
Compound2b: Yield 69%; white powder; mp 140–143 °C (EtOAc/hexane); IR νmax (KBr)/cm−1: 3330, 3050, 2960, 1642, 1580, 1495, 1425, 1360, 1226, 1052, 1022, 805, 746, 685; 1H NMR (500 MHz; DMSO-d6) δ 0.86 (3H, t, J = 6.8 CH3), 1.26–1.30 (10H, m, CH2), 1.46–1.48 (2H, m, CH2), 3.16–3.20 (2H, m, CH2NH), 6.73 (1H, d, J = 7.0 ArH), 7.16 (1H, dd, J = 1.6, 7.0 ArH), 7.26 (1H, d, J = 1.6 ArH), 8.09 (1H, s, NH), 9.07 (1H, s, ArOH), 9.40 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.1, 27.4, 29.4, 30.4, 32.4, 68.4, 118.2, 120.0, 128.4, 132.8, 151.8, 152.4, 170.8; FAB MS m/z 265 (M+); Anal. Found: C, 67.61; H, 8.82; N, 5.44%, Calc. for C15H23NO3: C, 67.88; H, 8.75; N, 5.28%.
Compound2c: Yield 74%; white powder; mp 142–145 °C (EtOAc/hexane); IR νmax (KBr)/cm−1: 3332, 3045, 2960, 1640, 1580, 1490, 1430, 1360, 1224, 1052, 1028, 805, 746, 685; 1H NMR (500 MHz; DMSO-d6) δ 0.85 (3H, t, J = 6.8 CH3), 1.22–1.28 (14H, m, CH2), 1.44–1.48 (2H, m, CH2), 3.18–3.20 (2H, m, CH2NH), 6.74 (1H, d, J = 7.0 ArH), 7.16 (1H, dd, J = 1.6, 7.0 ArH), 7.22 (1H, d, J = 1.6 ArH), 8.09 (1H, s, NH), 9.04 (1H, s, ArOH), 9.40 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.1, 27.6, 28.0, 29.4, 30.0, 30.4, 31.6, 68.4, 118.2, 121.0, 128.4, 132.8, 151.8, 152.4, 171.0; FAB MS m/z 293 (M+); Anal. Found: C, 69.41; H, 9.44; N, 4.94%, Calc. for C17H27NO3: C, 69.58; H, 9.29; N, 4.77%.
Compound2d: Yield 44%; white powder; mp 122–125 °C (EtOAc/hexane); IR νmax (KBr)/cm−1: 3328, 3040, 2965, 1640, 1580, 1495, 1425, 1360, 1224, 1092, 1028, 805, 734, 685; 1H NMR (500 MHz; DMSO-d6) δ 0.85 (3H, t, J = 6.8 CH3), 1.22–1.32 (18H, m, CH2), 1.44–1.46 (2H, m, CH2), 3.18–3.22 (2H, m, CH2NH), 6.74 (1H, d, J = 7.0 ArH), 7.18 (1H, dd, J = 1.6, 7.0 ArH), 7.22 (1H, d, J = 1.6 ArH), 8.09 (1H, s, NH), 9.04 (1H, s, ArOH), 9.42 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.1, 27.8, 28.4, 29.4, 30.4, 30.8, 31.6, 68.4, 118.2, 122.0, 128.4, 131.8, 152.0, 152.4, 171.0; FAB MS m/z 321 (M+); Anal. Found: C, 70.77; H, 9.88; N, 4.50%, Calc. for C19H31NO3: C, 70.97; H, 9.74; N, 4.36%.

4.3. Typical Procedure for Syntheses of 4a–d

After a solution of 3,4-dimethoxybenzoic acid (1.50 g, 8.23 mmol) and diphenylphosphoryl azide (DPPA) (1.88 mL, 8.72 mmol) together with triethylamine (1.65 mL, 11.9 mmol) in 1,2-dimethoxyethane (DME) (50 mL) was stirred for 3 h at room temperature, hexylamine (1.10 mL, 8.32 mmol) was added, followed by reflux for 1 h, and then extracted by dichloromethane. The extract was washed with water, dried over sodium sulfate, followed by evaporation under reduced pressure to afford a residue, which was washed with hexane to give 3a (1.04 g, 45%). To a stirred solution of 1-hexyl-3-[3,4-(dimethoxy)phenyl]urea (1.00 g, 3.57 mmol) in CH2Cl2 (40 mL) at 0 °C a solution of BBr3 (2.23 g, 8.90 mmol) in CH2Cl2 (40 mL) was added dropwise. After the reaction mixture was stirred for 13 h at room temperature, it was poured into ice-water. The mixture was stirred for a further 2 h at room temperature and extracted with dichloromethane. This dichloromethane extract was washed with water, dried over sodium sulfate, and evaporated under reduced pressure to yield a residue which, on recrystallization from MeOH and water, gave 4a as white powder (0.72 g, 79%).
Compound4a: Yield 79%; white powder; mp 160–162 °C (MeOH/water); IR νmax (KBr)/cm−1: 3330, 3045, 2960, 1650, 1584, 1495, 1425, 1364, 1226, 1050, 1022, 815, 695; 1H NMR (500 MHz; DMSO-d6) δ 0.86 (3H, t, J = 6.8 CH3), 1.24–1.28 (6H, m, CH2), 1.36–1.38 (2H, m, CH2), 2.98–3.04 (2H, m, CH2NH), 5.87–5.89 (1H, brs, NH), 6.51 (1H, dd, J = 1.6, 7.6 ArH), 6.55 (1H, d, J = 7.6 ArH), 6.91 (1H, d, J = 1.6 ArH), 7.93 (1H, s, NH), 8.32 (1H, s, ArOH), 8.78 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.1, 26.4, 31.7, 31.7, 69.6, 118.4, 120.2, 128.0, 132.6, 152.6, 153.4, 168.6; FAB MS m/z 252 (M+); Anal. Found: C, 61.62; H, 8.21; N, 11.05%, Calc. for C13H20N2O3: C, 61.87; H, 8.00; N, 11.10%.
Compound4b: Yield 86%; white powder; mp 152–155 °C (MeOH/water); IR νmax (KBr)/cm−1: 3334, 3045, 2960, 1650, 1584, 1498, 1425, 1360, 1226, 1050, 1020, 815, 695, 650; 1H NMR (500 MHz; DMSO-d6) δ 0.86 (3H, t, J = 6.8 CH3), 1.24–1.32 (10H, m, CH2), 1.38–1.40 (2H, m, CH2), 3.00–3.04 (2H, m, CH2NH), 5.87–5.90 (1H, brs, NH), 6.50 (1H, dd, J = 1.6, 7.6 ArH), 6.55 (1H, d, J = 7.6 ArH), 6.90 (1H, d, J = 1.6 ArH), 7.93 (1H, s, NH), 8.32 (1H, s, ArOH), 8.78 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.2, 27.4, 29.4, 30.0, 32.4, 69.4, 118.2, 120.0, 128.4, 132.8, 152.4, 153.4, 168.6; FAB MS m/z 280 (M+); Anal. Found: C, 64.13; H, 8.81; N, 9.77%, Calc. for C15H24N2O3: C, 64.25; H, 8.64; N, 9.99%.
Compound4c: Yield 94%; white powder; mp 148–152 °C (MeOH/water); IR νmax (KBr)/cm−1: 3330, 3045, 2965, 1650, 1584, 1500, 1425, 1356, 1226, 1050, 1020, 810, 695, 650; 1H NMR (500 MHz; DMSO-d6) δ 0.86 (3H, t, J = 6.8 CH3), 1.24–1.34 (14H, m, CH2), 1.38–1.40 (2H, m, CH2), 2.98–3.04 (2H, m, CH2NH), 5.87–5.92 (1H, brs, NH), 6.50 (1H, dd, J = 1.6, 7.8 ArH), 6.55 (1H, d, J = 7.8 ArH), 6.90 (1H, d, J = 1.6 ArH), 7.94 (1H, s, NH), 8.32 (1H, s, ArOH), 8.78 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.0, 27.6, 28.0, 29.4, 30.2, 30.4, 31.6, 68.4, 118.2, 121.0, 128.4, 132.8, 152.6, 153.6, 168.6; FAB MS m/z 308 (M+); Anal. Found: C, 65.96; H, 9.22; N, 8.89%, Calc. for C17H28N2O3: C, 66.19; H, 9.17; N, 9.08%.
Compound4d: Yield 74%; white powder; mp 130–132 °C (MeOH/water); IR νmax (KBr)/cm−1: 3335, 3045, 2965, 1650, 1584, 1504, 1428, 1356, 1226, 1050, 1022, 810, 695; 1H NMR (500 MHz; DMSO-d6) δ 0.86 (3H, t, J = 6.8 CH3), 1.26–1.34 (18H, m, CH2), 1.36–1.38 (2H, m, CH2), 2.98–3.02 (2H, m, CH2NH), 5.87–5.90 (1H, brs, NH), 6.50 (1H, dd, J = 1.6, 7.6 ArH), 6.58 (1H, d, J = 7.6 ArH), 6.88 (1H, d, J = 1.6 ArH), 7.94 (1H, s, NH), 8.32 (1H, s, ArOH), 8.78 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.1, 27.8, 28.4, 29.4, 30.2, 30.8, 31.6, 68.4, 118.2, 122.0, 128.4, 132.0, 152.2, 153.6, 168.6; FAB MS m/z 336 (M+); Anal. Found: C, 67.60; H, 9.74; N, 8.18%, Calc. for C19H32N2O3: C, 67.81; H, 9.60; N, 8.33%.

4.4. Typical Procedure for Syntheses of 6a–d

To a solution of 3,4-dimethylbenzoic acid (0.52 g, 2.84 mmol) and l-glutamic acid derivative (n = 6) (0.88 g, 2.85 mmol) in the presence of triethylamine (0.66 mL, 5.03 mmol) in Tetrahydrofuran (THF) (50 mL) in an ice bath was added a solution of diethyl cyanophosphonate (DECP) (0.45 mL, 3.03 mmol) in THF (10 mL). The reaction mixture was stirred for 20 h, then the solvent was removed to leave orange solid. This solid was suspended in aqueous 10% NaOH and stirred for 1 h, followed by filtration. The resulting solid was washed by 10% HCl solution and water to give white powder. Further purification was carried out by repeated washing with hexane to afford 5a (1.08 g, 79%). To a stirred solution of 5a (1.21 g, 2.54 mmol) in CH2Cl2 (40 mL) at 0 °C a solution of BBr3 (2.50 g, 10.0 mmol) in CH2Cl2 (40 mL) was added dropwise. After the reaction mixture was stirred for 20 h at room temperature, it was poured into ice-water, and then was stirred for a further 2 h at room temperature. The mixture was extracted with ethyl acetate. The extract was washed with water, dried over sodium sulfate, and then evaporated under reduced pressure to afford a residue which, on recrystallization from ethyl acetate and hexane, gave 6a as pale yellow powder (0.86 g, 76%).
Compound6a: Yield 76%; pale yellow powder; mp 155–158 °C (EtOAc/hexane); IR νmax (KBr)/cm−1: 3330, 3045, 2960, 1640, 1580, 1495, 1425, 1360, 1226, 805, 676; 1H NMR (500 MHz; DMSO-d6) δ 0.88 (3H, t, J = 6.8 CH3), 1.23–1.30 (12H, m, CH2), 1.48–1.52 (4H, m, CH2), 1.93–1.95 (2H, m, CH2), 2.30–2.33 (2H, m, CH2), 3.22–3.26 (4H, m, CH2NH), 4.32–4.34 (1H, m, CH), 6.32 (1H, t, J = 6.9 NH), 6.75 (1H, d, J = 7.0 ArH), 6.81 (1H, t, J = 6.9 NH), 7.23 (1H, dd, J = 1.6, 7.0 ArH), 7.30 (1H, d, J = 1.6 ArH), 8.15 (1H, t, J = 6.9 NH), 8.32 (1H, s, ArOH), 8.78 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.0, 23.4, 27.2, 31.8, 32.2, 68.4, 118.0, 122.2, 128.4, 132.8, 151.4, 152.8, 165.0, 169.0, 171.6; FAB MS m/z 449 (M+); Anal. Found: C, 63.94; H, 8.93; N, 9.25%, Calc. for C24H39N3O5: C, 64.10; H, 8.76; N, 9.35%.
Compound6b: Yield 50%; pale yellow powder; mp 148–152 °C (EtOAc/hexane); IR νmax (KBr)/cm−1: 3335, 3045, 2960, 1640, 1583, 1495, 1425, 1360, 1220, 1050, 805, 674; 1H NMR (500 MHz; DMSO-d6) δ 0.88 (3H, t, J = 6.8 CH3), 1.23–1.28 (20H, m, CH2), 1.50–1.52 (4H, m, CH2), 1.93–1.95 (2H, m, CH2), 2.31–2.33 (2H, m, CH2), 3.24–3.26 (4H, m, CH2NH), 4.34–4.36 (1H, m, CH), 6.32 (1H, t, J = 6.9 NH), 6.75 (1H, d, J = 7.0 ArH), 6.81 (1H, t, J = 6.9 NH), 7.23 (1H, dd, J = 1.6, 7.0 ArH), 7.30 (1H, d, J = 1.6 ArH), 8.15 (1H, t, J = 6.9 NH), 8.26 (1H, s, ArOH), 8.72 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.0, 27.2, 29.4, 30.4, 32.4, 68.0, 117.8, 120.0, 128.4, 132.8, 152.8, 164.8, 169.0, 171.6; FAB MS m/z 505 (M+); Anal. Found: C, 66.34; H, 9.53; N, 8.26%, Calc. for C28H47N3O5: C, 66.49; H, 9.39; N, 8.31%.
Compound6c: Yield 66%; pale yellow powder; mp 146–148 °C (EtOAc/hexane); IR νmax (KBr)/cm−1: 3332, 3045, 2964, 1640, 1580, 1495, 1430, 1355, 1220, 1050, 805, 670; 1H NMR (500 MHz; DMSO-d6) δ 0.86 (3H, t, J = 6.8 CH3), 1.20–1.28 (28H, m, CH2), 1.50–1.52 (4H, m, CH2), 1.90–1.95 (2H, m, CH2), 2.31–2.34 (2H, m, CH2), 3.24–3.26 (4H, m, CH2NH), 4.34–4.36 (1H, m, CH), 6.55 (1H, t, J = 6.9 NH), 6.72 (1H, d, J = 7.0 ArH), 6.91 (1H, t, J = 6.9 NH), 7.23 (1H, dd, J = 1.6, 7.0 ArH), 7.30 (1H, d, J = 1.6 ArH), 8.15 (1H, t, J = 6.9 NH), 8.26 (1H, s, ArOH), 8.70 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.0, 27.6, 28.2, 29.4, 30.0, 30.4, 31.6, 68.4, 118.2, 121.0, 128.0, 132.8, 152.8, 164.6, 169.0, 171.5; FAB MS m/z 561 (M+); Anal. Found: C, 68.14; H, 9.96; N, 7.30%, Calc. for C32H55N3O5: C, 68.40; H, 9.89; N, 7.48%.
Compound6d: Yield 62%; pale yellow powder; mp 130–133 °C (EtOAc/hexane); IR νmax (KBr)/cm−1: 3335, 3045, 2964, 1640, 1580, 1498, 1430, 1355, 1220, 1050, 805, 676; 1H NMR (500 MHz; DMSO-d6) δ 0.88 (3H, t, J = 6.8 CH3), 1.20–1.28 (36H, m, CH2), 1.50–1.52 (4H, m, CH2), 1.92–1.95 (2H, m, CH2), 2.31–2.34 (2H, m, CH2), 3.24–3.26 (4H, m, CH2NH), 4.26–4.30 (1H, m, CH), 6.43 (1H, t, J = 6.9 NH), 6.72 (1H, d, J = 7.0 ArH), 6.90 (1H, t, J = 6.9 NH), 7.23 (1H, dd, J = 1.6, 7.0 ArH), 7.32 (1H, d, J = 1.6 ArH), 8.15 (1H, t, J = 6.9 NH), 8.26 (1H, s, ArOH), 8.70 (1H, s, ArOH); 13C NMR (125 MHz, DMSO-d6) δ 14.2, 23.1, 27.6, 28.4, 29.4, 30.4, 30.6, 31.6, 68.4, 118.2, 122.2, 128.4, 131.8, 151.4, 152.8, 164.6, 169.0, 171.5; FAB MS m/z 617 (M+); Anal. Found: C, 69.87; H, 10.45; N, 6.72%, Calc. for C36H63N3O5: C, 69.96; H, 10.30; N, 6.80%.

4.5. Procedure for Synthesis of 9

To a solution of 4-carboxyphenylboroic acid (1.00 g, 6.03 mmol) and decylamine (0.83 mL, 6.30 mmol) together with triethylamine (1.30 mL, 10.0 mmol) in Dimethylformamide (DMF) (50 mL) in an ice bath was added a solution of diethyl cyanophosphonate (DECP) (1.10 mL, 7.24 mmol) in DMF (20 mL). After the reaction mixture was stirred for 24 h, the solvent was removed to leave the solid. This solid was suspended in aqueous 10% NaOH and stirred for 1 h, followed by filtration. The resulting solid was washed by 10% HCl solution and water to give white powder. Further purification was done by recrystallization with hexane to afford 9 as white powder (1.20 g, 74%).
Compound9: Yield 74%; white powder; mp 122–126 °C (hexane); IR νmax (KBr)/cm−1: 3335, 3045, 2964, 1642, 1584, 1495, 1425, 1364, 1226, 1050, 1020, 805, 680; 1H NMR (500 MHz; DMSO-d6) δ 0.85 (3H, t, J = 6.8 CH3), 1.24–1.30 (14H, m, CH2), 1.48–1.50 (2H, m, CH2), 3.20–3.22 (2H, m, CH2NH), 3.63 (2H, brs, OH), 7.77 (2H, d, J = 1.6, ArH), 7.83 (2H, d, J = 1.6 ArH), 8.43 (1H, t, J = 6.9 NH); 13C NMR (125 MHz, DMSO-d6) δ 14.0, 23.2, 27.8, 28.4, 29.4, 30.0, 30.8, 31.6, 68.4, 123.0, 128.4, 131.8, 142.0, 171.0; FAB MS m/z 304 (M+); Anal. Found: C, 66.57; H, 9.35; N, 4.40%, Calc. for C17H28BNO3: C, 66.88; H, 9.26; N, 4.59%.

Author Contributions

The idea for this work comes from A.T. A.T. wrote the paper. R.K. and D.Y. prepared the compounds and examined their gelation properties. K.A. performed SEM observation. The results were discussed with all authors.

Funding

This research was partially supported by JSPS KAKEN from the Ministry of Education, Culture, Sports, Science, and Technology in Japan (No. 15K05480).

Conflicts of Interest

The authors declare no conflicts of interest.

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Gels 05 00045 sch001 550
Scheme 1. Preparation of catechol derivatives and boronic acid.
Scheme 1. Preparation of catechol derivatives and boronic acid.
Gels 05 00045 sch001
Gels 05 00045 g001 550
Figure 1. Optical and SEM images of gels. (a) 4d in toluene; (b) 6d in DMSO.
Figure 1. Optical and SEM images of gels. (a) 4d in toluene; (b) 6d in DMSO.
Gels 05 00045 g001
Gels 05 00045 g002 550
Figure 2. Optical and SEM images of gel from 6d and 9 in chloroform.
Figure 2. Optical and SEM images of gel from 6d and 9 in chloroform.
Gels 05 00045 g002
Table
Table 1. Gelation properties of catechol derivatives in various solvents a.
Table 1. Gelation properties of catechol derivatives in various solvents a.
2a2b2c2d4a4b4c4d
HexaneIIIIIIII
CyclohexaneIIIIIIII
TolueneIPG(7.0)G(5.5)SG(4.5)G(3.5)G(2.5)
BenzeneSPG(7.0)G(5.0)SPGPGG(4.0)
ChloroformIPPG(3.0)IPPGG(3.0)
EtOHSSSSSSSG(1.0)
MeOHSSSSSSSS
DMFSSSSSSG(2.0)G(1.5)
DMSOSSSSSSSG(3.0)
a I: insoluble, P: precipitate, S: soluble, PG: partial gel, G: gel. The values given in parentheses are the minimum concentration (wt%) to achieve gelation.
Table
Table 2. Gelation properties of compounds (6a–d,7,8) in various solvents a.
Table 2. Gelation properties of compounds (6a–d,7,8) in various solvents a.
6a6b6c6d78
HexaneIIIIII
CyclohexaneIIIIII
TolueneIPPGG(4.5)SG(0.8)
BenzeneIPPGG(4.5)SG(0.8)
ChloroformISG(7.0)SSG(1.0)
EtOHSSPGSSG(1.5)
MeOHSSPGSSS
DMFSSSSSS
DMSOSSSG(3.0)SS
a I: insoluble, P: precipitate, S: soluble, PG: partial gel, G: gel. The values given in parentheses are the minimum concentration (wt%) to achieve gelation.
Table
Table 3. Gelation properties of 1:1 mixture of catechol derivatives (2c,2d,4b–d,6b–d) and boronic acid 9 a.
Table 3. Gelation properties of 1:1 mixture of catechol derivatives (2c,2d,4b–d,6b–d) and boronic acid 9 a.
2c/92b/94b/94c/94d/96b/96c/96d/9
TolueneSSG(7.0)G(6.5)G(4.5)PG(3.5)G(2.5)
BenzeneSSG(7.5)G(7.0)G(5.5)PG(3.5)G(2.5)
ChloroformPSPPGG(8.0)SG(4.0)G(4.0)
a I: insoluble, P: precipitate, S: soluble, PG: partial gel, G: gel. The values given in parentheses are the minimum concentration (wt%) to achieve gelation.

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Tsuge, A.; Kamoto, R.; Yakeya, D.; Araki, K. Gelating Abilities of Two-Component System of Catecholic Derivatives and a Boronic Acid. Gels 2019, 5, 45. https://doi.org/10.3390/gels5040045

AMA Style

Tsuge A, Kamoto R, Yakeya D, Araki K. Gelating Abilities of Two-Component System of Catecholic Derivatives and a Boronic Acid. Gels. 2019; 5(4):45. https://doi.org/10.3390/gels5040045

Chicago/Turabian Style

Tsuge, Akihiko, Ryota Kamoto, Daisuke Yakeya, and Koji Araki. 2019. "Gelating Abilities of Two-Component System of Catecholic Derivatives and a Boronic Acid" Gels 5, no. 4: 45. https://doi.org/10.3390/gels5040045

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