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Open AccessArticle

Temperature-Responsive Hydrogel-Coated Gold Nanoshells

Department of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USA
School of Integrative Engineering, Chung-Ang University, Seoul 156-756, Korea
Departments of Physics and Photon Science, Gwangju Institute of Science and Technology, 123 Chemdan-gwagiro (Oryong-dong), Buk-gu, Gwangju 500-712, Korea
Department of Chemical and Materials Engineering, National Central University, 300 Jhongda Road, Jhongli City 32001, Taiwan
Author to whom correspondence should be addressed.
Received: 15 January 2018 / Revised: 16 March 2018 / Accepted: 16 March 2018 / Published: 26 March 2018
(This article belongs to the Special Issue Stimuli-Responsive Gels)
Gold nanoshells (~160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at ~800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring. View Full-Text
Keywords: drug delivery; temperature responsive; gold nanoshell; hydrogel coating drug delivery; temperature responsive; gold nanoshell; hydrogel coating
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MDPI and ACS Style

Park, H.H.; Srisombat, L.-O.; Jamison, A.C.; Liu, T.; Marquez, M.D.; Park, H.; Lee, S.; Lee, T.-C.; Lee, T.R. Temperature-Responsive Hydrogel-Coated Gold Nanoshells. Gels 2018, 4, 28.

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