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Temperature-Responsive Hydrogel-Coated Gold Nanoshells

1
Department of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USA
2
School of Integrative Engineering, Chung-Ang University, Seoul 156-756, Korea
3
Departments of Physics and Photon Science, Gwangju Institute of Science and Technology, 123 Chemdan-gwagiro (Oryong-dong), Buk-gu, Gwangju 500-712, Korea
4
Department of Chemical and Materials Engineering, National Central University, 300 Jhongda Road, Jhongli City 32001, Taiwan
*
Author to whom correspondence should be addressed.
Received: 15 January 2018 / Revised: 16 March 2018 / Accepted: 16 March 2018 / Published: 26 March 2018
(This article belongs to the Special Issue Stimuli-Responsive Gels)
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Abstract

Gold nanoshells (~160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at ~800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring. View Full-Text
Keywords: drug delivery; temperature responsive; gold nanoshell; hydrogel coating drug delivery; temperature responsive; gold nanoshell; hydrogel coating
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Park, H.H.; Srisombat, L.-O.; Jamison, A.C.; Liu, T.; Marquez, M.D.; Park, H.; Lee, S.; Lee, T.-C.; Lee, T.R. Temperature-Responsive Hydrogel-Coated Gold Nanoshells. Gels 2018, 4, 28.

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