Temperature-Responsive Hydrogel-Coated Gold Nanoshells
AbstractGold nanoshells (~160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at ~800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring. View Full-Text
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Park, H.H.; Srisombat, L.-O.; Jamison, A.C.; Liu, T.; Marquez, M.D.; Park, H.; Lee, S.; Lee, T.-C.; Lee, T.R. Temperature-Responsive Hydrogel-Coated Gold Nanoshells. Gels 2018, 4, 28.
Park HH, Srisombat L-O, Jamison AC, Liu T, Marquez MD, Park H, Lee S, Lee T-C, Lee TR. Temperature-Responsive Hydrogel-Coated Gold Nanoshells. Gels. 2018; 4(2):28.Chicago/Turabian Style
Park, Hye H.; Srisombat, La-ongnuan; Jamison, Andrew C.; Liu, Tingting; Marquez, Maria D.; Park, Hansoo; Lee, Sungbae; Lee, Tai-Chou; Lee, T. R. 2018. "Temperature-Responsive Hydrogel-Coated Gold Nanoshells." Gels 4, no. 2: 28.
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