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Volume 10
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10.3390/gels10060358
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Article

TiO2–Alginate–Chitosan-Based Composites for Skin Tissue Engineering Applications

by
Emma Bobu
1,
Kata Saszet
1,2,
Zsejke-Réka Tóth
1,2,
Emőke Páll
3,
Tamás Gyulavári
4,
Lucian Baia
2,5,6,
Klara Magyari
2,7,* and
Monica Baia
5,6,*
1
Faculty of Physics, Doctoral School of Physics, Babeș-Bolyai University, M. Kogălniceanu 1, RO-400084 Cluj-Napoca, Romania
2
Nanostructured Materials and Bio-Nano-Interfaces Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, Treboniu Laurian 42, RO-400271 Cluj-Napoca, Romania
3
Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania
4
Department of Applied and Environmental Chemistry, University of Szeged, Rerrich B. sqr. 1., 6720 Szeged, Hungary
5
Faculty of Physics, Babeș-Bolyai University, M. Kogălniceanu 1, RO-400084 Cluj-Napoca, Romania
6
Institute of Research-Development-Innovation in Applied Natural Sciences, Babeș-Bolyai University, 400294 Cluj-Napoca, Romania
7
INSPIRE Research Platform InfoBioNano4Health & Biomedical Imaging, Babeș Bolyai University, Arany Janos 11, 400084 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Gels 2024, 10(6), 358; https://doi.org/10.3390/gels10060358
Submission received: 16 April 2024 / Revised: 13 May 2024 / Accepted: 17 May 2024 / Published: 22 May 2024
(This article belongs to the Special Issue Advances in Chitin- and Chitosan-Based Hydrogels)
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Abstract

The UV-B component of sunlight damages the DNA in skin cells, which can lead to skin cancer and premature aging. Therefore, it is necessary to use creams that also contain UV-active substances. Many sunscreens contain titanium dioxide due to its capacity to absorb UV-B wavelengths. In the present study, titan dioxide was introduced in alginate and chitosan–alginate hydrogel composites that are often involved as scaffold compositions in tissue engineering applications. Alginate and chitosan were chosen due to their important role in skin regeneration and skin protection. The composites were cross-linked with calcium ions and investigated using FT-IR, Raman, and UV–Vis spectroscopy. The stability of the obtained samples under solar irradiation for skin protection and regeneration was analyzed. Then, the hydrogel composites were assayed in vitro by immersing them in simulated body fluid and exposing them to solar simulator radiation for 10 min. The samples were found to be stable under solar light, and a thin apatite layer covered the surface of the sample with the two biopolymers and titanium dioxide. The in vitro cell viability assay suggested that the anatase phase in alginate and chitosan–alginate hydrogel composites have a positive impact.
Keywords: titanium dioxide; alginate; chitosan; hydrogel composites; hydroxyapatite layer; UV stability titanium dioxide; alginate; chitosan; hydrogel composites; hydroxyapatite layer; UV stability

Share and Cite

MDPI and ACS Style

Bobu, E.; Saszet, K.; Tóth, Z.-R.; Páll, E.; Gyulavári, T.; Baia, L.; Magyari, K.; Baia, M. TiO2–Alginate–Chitosan-Based Composites for Skin Tissue Engineering Applications. Gels 2024, 10, 358. https://doi.org/10.3390/gels10060358

AMA Style

Bobu E, Saszet K, Tóth Z-R, Páll E, Gyulavári T, Baia L, Magyari K, Baia M. TiO2–Alginate–Chitosan-Based Composites for Skin Tissue Engineering Applications. Gels. 2024; 10(6):358. https://doi.org/10.3390/gels10060358

Chicago/Turabian Style

Bobu, Emma, Kata Saszet, Zsejke-Réka Tóth, Emőke Páll, Tamás Gyulavári, Lucian Baia, Klara Magyari, and Monica Baia. 2024. "TiO2–Alginate–Chitosan-Based Composites for Skin Tissue Engineering Applications" Gels 10, no. 6: 358. https://doi.org/10.3390/gels10060358

APA Style

Bobu, E., Saszet, K., Tóth, Z.-R., Páll, E., Gyulavári, T., Baia, L., Magyari, K., & Baia, M. (2024). TiO2–Alginate–Chitosan-Based Composites for Skin Tissue Engineering Applications. Gels, 10(6), 358. https://doi.org/10.3390/gels10060358

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