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Medical Application of Substances Derived from Non-Pathogenic Fungi Aspergillus oryzae and A. luchuensis-Containing Koji

Graduate School of Advanced Health Sciences, Saga University, Saga 840-8502, Japan
Academic Editors: Katsuhiko Kitamoto and Yujiro Higuchi
J. Fungi 2021, 7(4), 243; https://doi.org/10.3390/jof7040243
Received: 27 February 2021 / Revised: 17 March 2021 / Accepted: 19 March 2021 / Published: 24 March 2021
(This article belongs to the Special Issue Aspergillus oryzae and related Koji molds)
Although most fungi cause pathogenicity toward human beings, dynasties of the East Asian region have domesticated and utilized specific fungi for medical applications. The Japanese dynasty and nation have domesticated and utilized koji fermented with non-pathogenic fungus Aspergillus oryzae for more than 1300 years. Recent research has elucidated that koji contains medicinal substances such as Taka-diastase, acid protease, koji glycosylceramide, kojic acid, oligosaccharides, ethyl-α-d-glucoside, ferulic acid, ergothioneine, pyroglutamyl leucine, pyranonigrin A, resistant proteins, deferriferrichrysin, polyamines, Bifidobacterium-stimulating peptides, angiotensin I-converting enzyme inhibitor peptides, 14-dehydroergosterol, beta-glucan, biotin, and citric acid. This review introduces potential medical applications of such medicinal substances to hyperlipidemia, diabetes, hypertension, cardiovascular and cognitive diseases, chronic inflammation, epidermal permeability barrier disruption, coronavirus disease 2019 (COVID-19), and anti-cancer therapy. View Full-Text
Keywords: medical application; koji; fermentation; non-pathogenic fungus; medicinal substances medical application; koji; fermentation; non-pathogenic fungus; medicinal substances
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MDPI and ACS Style

Kitagaki, H. Medical Application of Substances Derived from Non-Pathogenic Fungi Aspergillus oryzae and A. luchuensis-Containing Koji. J. Fungi 2021, 7, 243. https://doi.org/10.3390/jof7040243

AMA Style

Kitagaki H. Medical Application of Substances Derived from Non-Pathogenic Fungi Aspergillus oryzae and A. luchuensis-Containing Koji. Journal of Fungi. 2021; 7(4):243. https://doi.org/10.3390/jof7040243

Chicago/Turabian Style

Kitagaki, Hiroshi. 2021. "Medical Application of Substances Derived from Non-Pathogenic Fungi Aspergillus oryzae and A. luchuensis-Containing Koji" J. Fungi 7, no. 4: 243. https://doi.org/10.3390/jof7040243

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