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Article

The Emericellipsins A–E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungi

1
Laboratory for Taxonomic Study and Collection of Cultures of Microorganisms, Gause Institute of New Antibiotics, st. Bolshaya Pirogovskaya, 11, 119021 Moscow, Russia
2
Clinical Antituberculosis Center, Moscow Government Health Department Scientific, st. Stromynka, 10, 107014 Moscow, Russia
3
Laboratory of Neuroreceptors and Neuroregulators, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, st. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia
4
Department of Biology, Lomonosov Moscow State University, Leninskie Gory 1-12, 119234 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Academic Editors: Thomas Edison E. dela Cruz and Fahrul Huyop
J. Fungi 2021, 7(2), 153; https://doi.org/10.3390/jof7020153
Received: 27 December 2020 / Revised: 18 February 2021 / Accepted: 18 February 2021 / Published: 21 February 2021
(This article belongs to the Special Issue Fungi for Biotechnological Application and Environmental Cleanup)
Novel antimicrobial peptides with antifungal and cytotoxic activity were derived from the alkalophilic fungus Emericellopsis alkalina VKPM F1428. We previously reported that this strain produced emericellipsin A (EmiA), which has strong antifungal and cytotoxic properties. Further analyses of the metabolites obtained under a special alkaline medium resulted in the isolation of four new homologous (Emi B–E). In this work, we report the complete primary structure and detailed biological activity for the newly synthesized nonribosomal antimicrobial peptides called emericellipsins B–E. The inhibitory activity of themajor compound, EmiA, against drug-resistant pathogenic fungi was similar to that of amphotericin B (AmpB). At the same time, EmiA had no hemolytic activity towards human erythrocytes. In addition, EmiA demonstrated low cytotoxic activity towards the normal HPF line, but possessed cancer selectivity to the K-562 and HCT-116 cell lines. Emericillipsins from the alkalophilic fungus Emericellopsis alkaline are promising treatment alternatives to licensed antifungal drugs for invasive mycosis therapy, especially for multidrug-resistant aspergillosis and cryptococcosis. View Full-Text
Keywords: alkalophilic fungi; antifungal peptide; Emericellopsis alkalina; emericellipsins A–E; cytotoxic activity alkalophilic fungi; antifungal peptide; Emericellopsis alkalina; emericellipsins A–E; cytotoxic activity
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MDPI and ACS Style

Kuvarina, A.E.; Gavryushina, I.A.; Kulko, A.B.; Ivanov, I.A.; Rogozhin, E.A.; Georgieva, M.L.; Sadykova, V.S. The Emericellipsins A–E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungi. J. Fungi 2021, 7, 153. https://doi.org/10.3390/jof7020153

AMA Style

Kuvarina AE, Gavryushina IA, Kulko AB, Ivanov IA, Rogozhin EA, Georgieva ML, Sadykova VS. The Emericellipsins A–E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungi. Journal of Fungi. 2021; 7(2):153. https://doi.org/10.3390/jof7020153

Chicago/Turabian Style

Kuvarina, Anastasia E., Irina A. Gavryushina, Alexander B. Kulko, Igor A. Ivanov, Eugene A. Rogozhin, Marina L. Georgieva, and Vera S. Sadykova 2021. "The Emericellipsins A–E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungi" Journal of Fungi 7, no. 2: 153. https://doi.org/10.3390/jof7020153

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