Filamentous Fungal Infections in a Tertiary Care Setting: Epidemiology and Clinical Outcome
1
Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
2
Department of Infection Control and Hospital Epidemiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
3
Department for Evidence-Based Medicine and Evaluation, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, Austria
4
Department of Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
5
Clinical Institute for Physical Medicine and Rehabilitation, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, Dunant-Platz 1, 3100 St. Poelten, Austria
6
RTI International, 3040 East Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA
7
Clinical Department of Internal Medicine III, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, Dunant-Platz 1, 3100 St. Poelten, Austria
*
Author to whom correspondence should be addressed.
†
Those authors contributed equally to this paper.
J. Fungi 2021, 7(1), 40; https://doi.org/10.3390/jof7010040
Received: 20 November 2020
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Revised: 29 December 2020
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Accepted: 5 January 2021
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Published: 9 January 2021
(This article belongs to the Special Issue Epidemiology, Diagnosis of Fungal Infections)
Information on the distribution of filamentous fungal pathogens, which cause potential life-threatening invasive infections mostly in immunocompromised persons, is of great importance. The aim of this study was to evaluate the epidemiology and clinical outcome in patients with infections due to filamentous fungi at the University Hospital of Vienna, Austria. We conducted a retrospective observational study and consecutively included patients of any age with filamentous fungal infections between 2009 and 2017. The classification for probable and proven invasive filamentous fungal infections was based on the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group (EORTC) criteria or the expert opinion of an experienced clinical mycologist. We included 129 patients (median age: 52 years; 47.3% female) with episodes of 101 proven and probable invasive and 35 localized filamentous fungal infections (16 sinus, 14 eye, one ear, and four deep cutaneous). Aspergillus fumigatus alone accounted for 50.3% of the fungi, which was followed by the Mucorales group (13.7%) and Fusarium spp. (8.5%). Diagnosis was mainly based on culture findings. The lung was the most frequent site of infection. The 30-day and 90-day overall mortality of invasive fungal infections was 30.2% and 42.7%, respectively. We observed a high all-cause mortality among patients with invasive filamentous fungal infections. Prospective data collection in a nationwide registry would be necessary to provide important information on surveillance to clinicians and other decision-makers.
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MDPI and ACS Style
Van den Nest, M.; Wagner, G.; Riesenhuber, M.; Dolle, C.; Presterl, E.; Gartlehner, G.; Moertl, D.; Willinger, B. Filamentous Fungal Infections in a Tertiary Care Setting: Epidemiology and Clinical Outcome. J. Fungi 2021, 7, 40. https://doi.org/10.3390/jof7010040
AMA Style
Van den Nest M, Wagner G, Riesenhuber M, Dolle C, Presterl E, Gartlehner G, Moertl D, Willinger B. Filamentous Fungal Infections in a Tertiary Care Setting: Epidemiology and Clinical Outcome. Journal of Fungi. 2021; 7(1):40. https://doi.org/10.3390/jof7010040
Chicago/Turabian StyleVan den Nest, Miriam, Gernot Wagner, Martin Riesenhuber, Constantin Dolle, Elisabeth Presterl, Gerald Gartlehner, Deddo Moertl, and Birgit Willinger. 2021. "Filamentous Fungal Infections in a Tertiary Care Setting: Epidemiology and Clinical Outcome" Journal of Fungi 7, no. 1: 40. https://doi.org/10.3390/jof7010040
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