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Open AccessCase Report
J. Fungi 2018, 4(4), 114; https://doi.org/10.3390/jof4040114

Beta-Glucanemia after Coronary Artery Bypass Graft Surgery: A Case Report

1
Department of Infectious Disease, Stanford University Hospital, Palo Alto, California, CA 94305, USA
2
Washington Hospital, Fremont, California, CA 94538, USA
3
Research Laboratory, Clinical Development Department, Associates of Cape Cod, Falmouth, Massachusetts, MA 02536, USA
*
Author to whom correspondence should be addressed.
Received: 16 August 2018 / Revised: 21 September 2018 / Accepted: 27 September 2018 / Published: 2 October 2018
Full-Text   |   PDF [182 KB, uploaded 2 October 2018]

Abstract

Blood salvage techniques are increasingly being used during surgical procedures to reduce the need for exogenous blood products. The blood recovered from the surgical field through aspiration or absorption by surgical sponges is reinfused into a patient. A 65-year old patient who underwent coronary artery bypass grafting using blood salvage techniques developed a fever on post-op day 3 and was noted to have an elevated β-d-glucan level, a marker of systemic fungal infections. Ultimately, no fungal infection was identified, β-d-glucan levels slowly decreased and the patient demonstrated clinical improvement. To determine whether blood salvage procedures led to his elevated β-d-glucan levels, the surgical sponges were tested for elutable levels of β-d-glucan. The β-d-glucan content of the eluents was measured using the Fungitell® IVD kit (Associates of Cape Cod, Inc.; East Falmouth, MA). The β-d-glucan levels were found to be in concentrations 10,000-times greater than the limit of detection for human serum. While various studies have demonstrated both the immunomodulatory and pro-inflammatory effects of β-d-glucan, the physiologic impact of such high levels of β-d-glucan post-operatively remains unknown. Additionally, the persistence of detectable β-d-glucan up to several weeks after surgical procedures presents a challenge for the diagnosis of invasive fungal infections. Further studies are needed to assess the beta-glucanemia-related safety of surgical materials and their potential biological effects. View Full-Text
Keywords: beta-glucan; CABG; blood conservation beta-glucan; CABG; blood conservation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Styczynski, A.; Bonilla, H.; Treynor, E.; Shashank, J.; Zhang, Y.; Finkelman, M. Beta-Glucanemia after Coronary Artery Bypass Graft Surgery: A Case Report. J. Fungi 2018, 4, 114.

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