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Present and Future Therapy of Cryptococcus Infections

Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Author to whom correspondence should be addressed.
J. Fungi 2018, 4(3), 79;
Received: 19 May 2018 / Revised: 25 June 2018 / Accepted: 26 June 2018 / Published: 3 July 2018
(This article belongs to the Special Issue Treatments for Fungal Infections)
PDF [249 KB, uploaded 3 July 2018]


Cryptococcal infections burden the immunocompromised population with unacceptably high morbidity and mortality. This population includes HIV-infected individuals and those undergoing organ transplants, as well as seemingly immunocompetent patients (non-HIV, non-transplant). These groups are difficult to manage with the current therapeutic options and strategies, particularly in resource-limited settings. New trials aimed at providing the best treatment strategies for resource-limited countries that will reduce costs and adverse reactions have focused on decreasing the length of therapy and using more readily accessible antifungal agents such as fluconazole. Furthermore, the emergence of antifungal resistance poses another challenge for successful treatment and may require the development of new agents for improved management. This review will discuss the principles of management, current and future antifungal agents, as well as emerging techniques and future directions of care for this deadly infection. View Full-Text
Keywords: Cryptococcus; cryptococcosis; cryptococcal meningitis; antifungal therapy; antifungal agents Cryptococcus; cryptococcosis; cryptococcal meningitis; antifungal therapy; antifungal agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Mourad, A.; Perfect, J.R. Present and Future Therapy of Cryptococcus Infections. J. Fungi 2018, 4, 79.

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