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The Human Mucosal Mycobiome and Fungal Community Interactions

Centre for Host-Microbiome Interactions, Dental Institute, King’s College London, London SE1 9RT, UK
Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden
Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
Author to whom correspondence should be addressed.
J. Fungi 2017, 3(4), 56;
Received: 29 August 2017 / Revised: 23 September 2017 / Accepted: 5 October 2017 / Published: 7 October 2017
(This article belongs to the Special Issue Mucosal Fungal Infections)
With the advent of high-throughput sequencing techniques, the astonishing extent and complexity of the microbial communities that reside within and upon us has begun to become clear. Moreover, with advances in computing and modelling methods, we are now beginning to grasp just how dynamic our interactions with these communities are. The diversity of both these communities and their interactions—both within the community and with us—are dependent on a multitude of factors, both microbial- and host-mediated. Importantly, it is becoming clear that shifts in the makeup of these communities, or their responses, are linked to different disease states. Although much of the work to define these interactions and links has been investigating bacterial communities, recently there has been significant growth in the body of knowledge, indicating that shifts in the host fungal communities (mycobiome) are also intimately linked to disease status. In this review, we will explore these associations, along with the interactions between fungal communities and their human and microbial habitat, and discuss the future applications of systems biology in determining their role in disease status. View Full-Text
Keywords: mycobiome; microbiome; bacterial-fungal interactions; fungal-fungal interactions; host-fungal interactions; systems biology mycobiome; microbiome; bacterial-fungal interactions; fungal-fungal interactions; host-fungal interactions; systems biology
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Witherden, E.A.; Shoaie, S.; Hall, R.A.; Moyes, D.L. The Human Mucosal Mycobiome and Fungal Community Interactions. J. Fungi 2017, 3, 56.

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