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Immune Recognition of Fungal Polysaccharides

Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada
Department of Medicine, Infectious Diseases and Immunity in Global Health Program, Centre for Translational Biology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada
Meakins-Christie Laboratories, Department of Medicine and Division of Experimental Medicine, McGill University, Montréal, QC H4A 3J1, Canada
Department of Critical Care and Research, Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada
Author to whom correspondence should be addressed.
J. Fungi 2017, 3(3), 47;
Received: 31 July 2017 / Revised: 21 August 2017 / Accepted: 23 August 2017 / Published: 28 August 2017
(This article belongs to the Special Issue Host–Fungus Interactions)
The incidence of fungal infections has dramatically increased in recent years, in large part due to increased use of immunosuppressive medications, as well as aggressive medical and surgical interventions that compromise natural skin and mucosal barriers. There are relatively few currently licensed antifungal drugs, and rising resistance to these agents has led to interest in the development of novel preventative and therapeutic strategies targeting these devastating infections. One approach to combat fungal infections is to augment the host immune response towards these organisms. The polysaccharide-rich cell wall is the initial point of contact between fungi and the host immune system, and therefore, represents an important target for immunotherapeutic approaches. This review highlights the advances made in our understanding of the mechanisms by which the immune system recognizes and interacts with exopolysaccharides produced by four of the most common fungal pathogens: Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, and Histoplasma capsulatum. Work to date suggests that inner cell wall polysaccharides that play an important structural role are the most conserved across diverse members of the fungal kingdom, and elicit the strongest innate immune responses. The immune system senses these carbohydrates through receptors, such as lectins and complement proteins. In contrast, a greater diversity of polysaccharides is found within the outer cell walls of pathogenic fungi. These glycans play an important role in immune evasion, and can even induce anti-inflammatory host responses. Further study of the complex interactions between the host immune system and the fungal polysaccharides will be necessary to develop more effective therapeutic strategies, as well as to explore the use of immunosuppressive polysaccharides as therapeutic agents to modulate inflammation. View Full-Text
Keywords: polysaccharide; immune receptor; fungal cell wall; Aspergillus fumigatus; Candida albicans; Cryptococcus neoformans; Histoplasma capsulatum polysaccharide; immune receptor; fungal cell wall; Aspergillus fumigatus; Candida albicans; Cryptococcus neoformans; Histoplasma capsulatum
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MDPI and ACS Style

Snarr, B.D.; Qureshi, S.T.; Sheppard, D.C. Immune Recognition of Fungal Polysaccharides. J. Fungi 2017, 3, 47.

AMA Style

Snarr BD, Qureshi ST, Sheppard DC. Immune Recognition of Fungal Polysaccharides. Journal of Fungi. 2017; 3(3):47.

Chicago/Turabian Style

Snarr, Brendan D., Salman T. Qureshi, and Donald C. Sheppard. 2017. "Immune Recognition of Fungal Polysaccharides" Journal of Fungi 3, no. 3: 47.

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