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Innate Immune Responses to Cryptococcus

Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J. Fungi 2017, 3(3), 35; https://doi.org/10.3390/jof3030035
Received: 24 May 2017 / Revised: 21 June 2017 / Accepted: 29 June 2017 / Published: 2 July 2017
(This article belongs to the Special Issue Host–Fungus Interactions)
Cryptococcus species are encapsulated fungi found in the environment that predominantly cause disease in immunocompromised hosts after inhalation into the lungs. Even with contemporary antifungal regimens, patients with cryptococcosis continue to have high morbidity and mortality rates. The development of more effective therapies may depend on our understanding of the cellular and molecular mechanisms by which the host promotes sterilizing immunity against the fungus. This review will highlight our current knowledge of how Cryptococcus, primarily the species C. neoformans, is sensed by the mammalian host and how subsequent signaling pathways direct the anti-cryptococcal response by effector cells of the innate immune system. View Full-Text
Keywords: Cryptococcus; innate immune response; fungal recognition; host-fungus interactions Cryptococcus; innate immune response; fungal recognition; host-fungus interactions
MDPI and ACS Style

Heung, L.J. Innate Immune Responses to Cryptococcus. J. Fungi 2017, 3, 35.

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