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J. Fungi 2017, 3(3), 35;

Innate Immune Responses to Cryptococcus

Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Received: 24 May 2017 / Revised: 21 June 2017 / Accepted: 29 June 2017 / Published: 2 July 2017
(This article belongs to the Special Issue Host–Fungus Interactions)
Full-Text   |   PDF [311 KB, uploaded 2 July 2017]


Cryptococcus species are encapsulated fungi found in the environment that predominantly cause disease in immunocompromised hosts after inhalation into the lungs. Even with contemporary antifungal regimens, patients with cryptococcosis continue to have high morbidity and mortality rates. The development of more effective therapies may depend on our understanding of the cellular and molecular mechanisms by which the host promotes sterilizing immunity against the fungus. This review will highlight our current knowledge of how Cryptococcus, primarily the species C. neoformans, is sensed by the mammalian host and how subsequent signaling pathways direct the anti-cryptococcal response by effector cells of the innate immune system. View Full-Text
Keywords: Cryptococcus; innate immune response; fungal recognition; host-fungus interactions Cryptococcus; innate immune response; fungal recognition; host-fungus interactions
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Heung, L.J. Innate Immune Responses to Cryptococcus. J. Fungi 2017, 3, 35.

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