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NK Cells and Their Role in Invasive Mold Infection

Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt 60590, Germany
Department of Clinical and Experimental Medicine, Unit of Pediatric Hematology and Oncology, University of Catania, Catania 95131, Italy
Author to whom correspondence should be addressed.
Academic Editor: Adilia Warris
J. Fungi 2017, 3(2), 25;
Received: 19 April 2017 / Revised: 16 May 2017 / Accepted: 17 May 2017 / Published: 19 May 2017
(This article belongs to the Special Issue Host–Fungus Interactions)
There is growing evidence that Natural Killer (NK) cells exhibit in vitro activity against both Aspergillus and non-Aspergillus molds. Cytotoxic molecules such as NK cell-derived perforin seem to play an important role in the antifungal activity. In addition, NK cells release a number of cytokines upon stimulation by fungi, which modulate both innate and adaptive host immune responses. Whereas the in vitro data of the antifungal activity of NK cells are supported by animal studies, clinical data are scarce to date. View Full-Text
Keywords: NK cells; mold infection; host fungus interactions; lymphocytes NK cells; mold infection; host fungus interactions; lymphocytes
MDPI and ACS Style

Schmidt, S.; Condorelli, A.; Koltze, A.; Lehrnbecher, T. NK Cells and Their Role in Invasive Mold Infection. J. Fungi 2017, 3, 25.

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