Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review
Abstract
:1. Introduction
2. Physiopathology
3. Mycology
4. Different Forms of Dermatophytosis
- Localised to single or multiple perifollicular (hair follicle) sites e.g., Majocchi granuloma, nodular perifolliculitis.
- Deep dermatophytosis, not confined to the perifollicular area e.g., in the presence of immunosuppression or CARD9 deficiency, with or without dissemination to extra-cutaneous sites.
5. Diagnosis of Severe Dermatophytosis
6. Underlying Conditions Responsible for Severe Dermatophytsosis
Underlying Conditions Associated with Severe Dermatophytosis | Number of Cases | Clinical Involvement | References |
---|---|---|---|
Solid organ transplant | 28 | Skin | [22,26,27,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53] |
HIV infection | 9 | Skin | [38,54,55,56,57,58,59,60] |
Systemic corticosteroid treatment | 7 | Skin | [21,31,61,62,63,64,65] |
Others immunosuppressive treatments ± steroid | 6 | Skin/nodes | [19,25,66,67,68,69] |
Hematological malignancy | 7 | Skin | [70,71,72,73,74] |
Liver disease | 3 | Skin | [17,75,76] |
Topical steroid only | 1 | Skin/nodes | [77] |
Cushing disease, congenital adrenal hyperplasia | 2 | Skin | [78,79] |
Atopy | 1 | Skin | [80] |
Diabetes mellitus | 1 | Skin | [64] |
CARD9 deficiency | 19 | Skin/nodes/organs | [11,23,81,82,83,84,85,86,87] |
6.1. Solid Organ Transplant
6.2. HIV Infection
6.3. Other Secondary Immunodeficiencies
6.4. Primary Immunodeficiency
7. Treatment of Severe Dermatophytosis
8. Conclusions
Author Contributions
Conflicts of Interest
References
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Rouzaud, C.; Hay, R.; Chosidow, O.; Dupin, N.; Puel, A.; Lortholary, O.; Lanternier, F. Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review. J. Fungi 2016, 2, 4. https://doi.org/10.3390/jof2010004
Rouzaud C, Hay R, Chosidow O, Dupin N, Puel A, Lortholary O, Lanternier F. Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review. Journal of Fungi. 2016; 2(1):4. https://doi.org/10.3390/jof2010004
Chicago/Turabian StyleRouzaud, Claire, Roderick Hay, Olivier Chosidow, Nicolas Dupin, Anne Puel, Olivier Lortholary, and Fanny Lanternier. 2016. "Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review" Journal of Fungi 2, no. 1: 4. https://doi.org/10.3390/jof2010004
APA StyleRouzaud, C., Hay, R., Chosidow, O., Dupin, N., Puel, A., Lortholary, O., & Lanternier, F. (2016). Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review. Journal of Fungi, 2(1), 4. https://doi.org/10.3390/jof2010004