Candida glabrata, Friend and Foe
School of Applied Sciences, RMIT University, Bundoora, Victoria 3083, Australia
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Academic Editor: John R. Perfect
J. Fungi 2015, 1(2), 277-292; https://doi.org/10.3390/jof1020277
Received: 18 August 2015 / Revised: 7 September 2015 / Accepted: 9 September 2015 / Published: 16 September 2015
(This article belongs to the Special Issue Yeasts Are Beasts)
Candida glabrata is mostly good, but, at times, it is an opportunistic pathogen. Previously known as Torulopsis glabrata, it enjoyed a good reputation and was even present in starter cultures. Its haploid genome and lack of mating made it an attractive challenge for yeast genetics studies. However, more recently it has become better known due to its character as an emerging cause of candidiasis, and for its resistance to multidrugs that are employed for candidiasis treatment. While now classified as Candida glabrata, it is still not a good fit and tends to stand alone as a very unique yeast. In terms of sequence, it is dissimilar to other Candida yeast and most similar to Saccharomyces cerevisiae.
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Keywords:
antifungal resistance; azole; candidiasis; ergosterol; opportunistic pathogen; starter culture; statins; Torulopsis; yeast
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MDPI and ACS Style
Tam, P.; Gee, K.; Piechocinski, M.; Macreadie, I. Candida glabrata, Friend and Foe. J. Fungi 2015, 1, 277-292.
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