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Systematic Review

Performance of Copeptin for Early Diagnosis of Acute Coronary Syndromes: A Systematic Review and Meta-Analysis of 14,139 Patients

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Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, 03-411 Warsaw, Poland
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Research Unit, Maria Sklodowska-Curie Bialystok Oncology Center, 15-027 Bialystok, Poland
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Research Unit, Polish Society of Disaster Medicine, 05-806 Warsaw, Poland
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1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland
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Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Center, 1105 Amsterdam, The Netherlands
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Students Research Club, Maria Sklodowska-Curie Medical Academy, 04-311 Warsaw, Poland
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Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, 41121 Modena, Italy
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Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX 77030, USA
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1st Department of Cardiology, Medical University of Gdansk, 80-211 Gdansk, Poland
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Institute of Clinical Medicine, Maria Sklodowska-Curie Medical Academy, 00-001 Warsaw, Poland
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Author to whom correspondence should be addressed.
Academic Editor: John A. Baugh
J. Cardiovasc. Dev. Dis. 2022, 9(1), 6; https://doi.org/10.3390/jcdd9010006
Received: 12 November 2021 / Revised: 18 December 2021 / Accepted: 23 December 2021 / Published: 27 December 2021
Diagnosis of acute coronary syndrome (ACS) based on copeptin level may enable one to confirm or rule-out acute myocardial infarction (AMI) with higher sensitivity and specificity, which may in turn further reduce mortality rate and decrease the economic costs of ACS treatment. We conducted a systematic review and meta-analysis to investigate the relationship between copeptin levels and type of ACS. We searched Scopus, PubMed, Web of Science, Embase, and Cochrane to locate all articles published up to 10 October 2021. We evaluated a meta-analysis with random-effects models to evaluate differences in copeptin levels. A total of 14,139 patients (4565 with ACS) were included from twenty-seven studies. Copeptin levels in AMI and non-AMI groups varied and amounted to 68.7 ± 74.7 versus 14.8 ± 19.9 pmol/L (SMD = 2.63; 95% CI: 2.02 to 3.24; p < 0.001). Copeptin levels in the AMI group was higher than in the unstable angina (UAP) group, at 51.9 ± 52.5 versus 12.8 ± 19.7 pmol/L (SMD = 1.53; 95% CI: 0.86 to 2.20; p < 0.001). Copeptin levels in ST-elevation myocardial infarction (STEMI) versus non-ST elevation myocardial infarction (NSTEMI) patient groups were 54.8 ± 53.0 versus 28.7 ± 46.8 pmol/L, respectively (SMD = 1.69; 95% CI: = 0.70 to 4.09; p = 0.17). In summary, elevated copeptin levels were observed in patients with ACS compared with patients without ACS. Given its clinical value, copeptin levels may be included in the assessment of patients with ACS as well as for the initial differentiation of ACS. View Full-Text
Keywords: copeptin; biomarker; acute coronary syndrome; acute myocardial infarction; systematic review copeptin; biomarker; acute coronary syndrome; acute myocardial infarction; systematic review
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MDPI and ACS Style

Szarpak, L.; Lapinski, M.; Gasecka, A.; Pruc, M.; Drela, W.L.; Koda, M.; Denegri, A.; Peacock, F.W.; Jaguszewski, M.J.; Filipiak, K.J. Performance of Copeptin for Early Diagnosis of Acute Coronary Syndromes: A Systematic Review and Meta-Analysis of 14,139 Patients. J. Cardiovasc. Dev. Dis. 2022, 9, 6. https://doi.org/10.3390/jcdd9010006

AMA Style

Szarpak L, Lapinski M, Gasecka A, Pruc M, Drela WL, Koda M, Denegri A, Peacock FW, Jaguszewski MJ, Filipiak KJ. Performance of Copeptin for Early Diagnosis of Acute Coronary Syndromes: A Systematic Review and Meta-Analysis of 14,139 Patients. Journal of Cardiovascular Development and Disease. 2022; 9(1):6. https://doi.org/10.3390/jcdd9010006

Chicago/Turabian Style

Szarpak, Lukasz, Marcin Lapinski, Aleksandra Gasecka, Michal Pruc, Wiktoria L. Drela, Mariusz Koda, Andrea Denegri, Frank W. Peacock, Miłosz J. Jaguszewski, and Krzysztof J. Filipiak. 2022. "Performance of Copeptin for Early Diagnosis of Acute Coronary Syndromes: A Systematic Review and Meta-Analysis of 14,139 Patients" Journal of Cardiovascular Development and Disease 9, no. 1: 6. https://doi.org/10.3390/jcdd9010006

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