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Article

Persistent Ventricle Partitioning in the Adult Zebrafish Heart

1
Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland
2
Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine and Children’s Hospital Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Cardiovasc. Dev. Dis. 2021, 8(4), 41; https://doi.org/10.3390/jcdd8040041
Received: 15 March 2021 / Revised: 2 April 2021 / Accepted: 7 April 2021 / Published: 9 April 2021
(This article belongs to the Special Issue Zebrafish Heart Development, Regeneration, and Disease Modelling)
The vertebrate heart integrates cells from the early-differentiating first heart field (FHF) and the later-differentiating second heart field (SHF), both emerging from the lateral plate mesoderm. In mammals, this process forms the basis for the development of the left and right ventricle chambers and subsequent chamber septation. The single ventricle-forming zebrafish heart also integrates FHF and SHF lineages during embryogenesis, yet the contributions of these two myocardial lineages to the adult zebrafish heart remain incompletely understood. Here, we characterize the myocardial labeling of FHF descendants in both the developing and adult zebrafish ventricle. Expanding previous findings, late gastrulation-stage labeling using drl-driven CreERT2 recombinase with a myocardium-specific, myl7-controlled, loxP reporter results in the predominant labeling of FHF-derived outer curvature and the right side of the embryonic ventricle. Raised to adulthood, such lineage-labeled hearts retain broad areas of FHF cardiomyocytes in a region of the ventricle that is positioned at the opposite side to the atrium and encompasses the apex. Our data add to the increasing evidence for a persisting cell-based compartmentalization of the adult zebrafish ventricle even in the absence of any physical boundary. View Full-Text
Keywords: heart development; first heart field; lineage tracing; cardiac ventricle; zebrafish heart development; first heart field; lineage tracing; cardiac ventricle; zebrafish
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MDPI and ACS Style

Pfefferli, C.; Moran, H.R.; Felker, A.; Mosimann, C.; Jaźwińska, A. Persistent Ventricle Partitioning in the Adult Zebrafish Heart. J. Cardiovasc. Dev. Dis. 2021, 8, 41. https://doi.org/10.3390/jcdd8040041

AMA Style

Pfefferli C, Moran HR, Felker A, Mosimann C, Jaźwińska A. Persistent Ventricle Partitioning in the Adult Zebrafish Heart. Journal of Cardiovascular Development and Disease. 2021; 8(4):41. https://doi.org/10.3390/jcdd8040041

Chicago/Turabian Style

Pfefferli, Catherine, Hannah R. Moran, Anastasia Felker, Christian Mosimann, and Anna Jaźwińska. 2021. "Persistent Ventricle Partitioning in the Adult Zebrafish Heart" Journal of Cardiovascular Development and Disease 8, no. 4: 41. https://doi.org/10.3390/jcdd8040041

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