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Vulnerable Plaque, Characteristics, Detection, and Potential Therapies

Department of Medicine, Faculty of Medicine and Research Institute of the McGill University, Health Centre, McGill University, Montreal, QC H4A 3J1, Canada
J. Cardiovasc. Dev. Dis. 2019, 6(3), 26; https://doi.org/10.3390/jcdd6030026
Received: 12 June 2019 / Revised: 21 July 2019 / Accepted: 24 July 2019 / Published: 27 July 2019
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PDF [1761 KB, uploaded 27 July 2019]
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Abstract

Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention of atherosclerotic vascular disease. It remains a challenge to determine at an early stage if atherosclerotic plaque will become unstable and vulnerable. The arrival of molecular imaging is receiving more attention, considering it allows for a better understanding of the biology of human plaque and vulnerabilities. Various plaque therapies with common goals have been tested in high-risk patients with cardiovascular disease. In this work, the process of plaque instability, along with current technologies for sensing and predicting high-risk plaques, is debated. Updates on potential novel therapeutic approaches are also summarized. View Full-Text
Keywords: plaque; atherosclerosis; regression; thrombosis; cardiovascular disease plaque; atherosclerosis; regression; thrombosis; cardiovascular disease
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Hafiane, A. Vulnerable Plaque, Characteristics, Detection, and Potential Therapies. J. Cardiovasc. Dev. Dis. 2019, 6, 26.

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