Next Article in Journal
Cardiac Fibroblast p38 MAPK: A Critical Regulator of Myocardial Remodeling
Previous Article in Journal
Development and Psychometric Evaluation of the Cardiac Rehabilitation Adherence Tool (CRAT)
Open AccessReview

Vulnerable Plaque, Characteristics, Detection, and Potential Therapies

Department of Medicine, Faculty of Medicine and Research Institute of the McGill University, Health Centre, McGill University, Montreal, QC H4A 3J1, Canada
J. Cardiovasc. Dev. Dis. 2019, 6(3), 26;
Received: 12 June 2019 / Revised: 21 July 2019 / Accepted: 24 July 2019 / Published: 27 July 2019
PDF [1761 KB, uploaded 27 July 2019]


Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention of atherosclerotic vascular disease. It remains a challenge to determine at an early stage if atherosclerotic plaque will become unstable and vulnerable. The arrival of molecular imaging is receiving more attention, considering it allows for a better understanding of the biology of human plaque and vulnerabilities. Various plaque therapies with common goals have been tested in high-risk patients with cardiovascular disease. In this work, the process of plaque instability, along with current technologies for sensing and predicting high-risk plaques, is debated. Updates on potential novel therapeutic approaches are also summarized. View Full-Text
Keywords: plaque; atherosclerosis; regression; thrombosis; cardiovascular disease plaque; atherosclerosis; regression; thrombosis; cardiovascular disease

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Hafiane, A. Vulnerable Plaque, Characteristics, Detection, and Potential Therapies. J. Cardiovasc. Dev. Dis. 2019, 6, 26.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top