Next Article in Journal
Acknowledgement to Reviewers of Journal of Cardiovascular Development and Disease in 2017
Next Article in Special Issue
Cyclic Nucleotide-Directed Protein Kinases in Cardiovascular Inflammation and Growth
Previous Article in Journal
Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal
Previous Article in Special Issue
Function of Adenylyl Cyclase in Heart: the AKAP Connection
Open AccessFeature PaperReview

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2018, 5(1), 4;
Received: 29 December 2017 / Revised: 16 January 2018 / Accepted: 17 January 2018 / Published: 19 January 2018
(This article belongs to the Special Issue Cyclic Nucleotide Signaling and the Cardiovascular System)
Cyclic nucleotides 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques. View Full-Text
Keywords: cAMP; cGMP; phosphodiesterase; FRET; imaging; cross-talk cAMP; cGMP; phosphodiesterase; FRET; imaging; cross-talk
Show Figures

Figure 1

MDPI and ACS Style

Pavlaki, N.; Nikolaev, V.O. Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes. J. Cardiovasc. Dev. Dis. 2018, 5, 4.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop