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J. Cardiovasc. Dev. Dis. 2018, 5(1), 12; https://doi.org/10.3390/jcdd5010012

A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection

Département de Pharmacologie et de Toxicologie, Faculté de Biologie et de Médecine, Lausanne 1005, Switzerland
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Received: 12 January 2018 / Revised: 2 February 2018 / Accepted: 6 February 2018 / Published: 8 February 2018
(This article belongs to the Special Issue Cyclic Nucleotide Signaling and the Cardiovascular System)
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Abstract

Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis. In this context, A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that facilitate the spatiotemporal activation of the cyclic adenosine monophosphate (AMP)-dependent protein kinase (PKA) and other transduction enzymes involved in cardiac remodeling. AKAP-Lbc, a cardiac enriched anchoring protein, has been shown to act as a key coordinator of the activity of signaling pathways involved in cardiac protection and remodeling. This review will summarize and discuss recent advances highlighting the role of the AKAP-Lbc signalosome in orchestrating adaptive responses in the stressed heart. View Full-Text
Keywords: A-kinase anchoring protein (AKAP); protein kinase A; cyclic AMP; cardiomyocyte; cardiac protection; signal transduction A-kinase anchoring protein (AKAP); protein kinase A; cyclic AMP; cardiomyocyte; cardiac protection; signal transduction
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Diviani, D.; Osman, H.; Reggi, E. A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection. J. Cardiovasc. Dev. Dis. 2018, 5, 12.

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