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Open AccessFeature PaperReview

Functions of PDE3 Isoforms in Cardiac Muscle

Department of Internal Medicine/Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT 841132, USA
Vascular Biology and Hypertension Branch, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
Department of Molecular Biotechnology and Health Sciences, Center for Molecular Biotechnology, University of Turin, 10126 Turin, Italy
Author to whom correspondence should be addressed.
Beginning 18 February 2018: Sidra Medical Research Center, Doha, Qatar.
J. Cardiovasc. Dev. Dis. 2018, 5(1), 10;
Received: 9 January 2018 / Revised: 30 January 2018 / Accepted: 1 February 2018 / Published: 6 February 2018
(This article belongs to the Special Issue Cyclic Nucleotide Signaling and the Cardiovascular System)
Isoforms in the PDE3 family of cyclic nucleotide phosphodiesterases have important roles in cyclic nucleotide-mediated signalling in cardiac myocytes. These enzymes are targeted by inhibitors used to increase contractility in patients with heart failure, with a combination of beneficial and adverse effects on clinical outcomes. This review covers relevant aspects of the molecular biology of the isoforms that have been identified in cardiac myocytes; the roles of these enzymes in modulating cAMP-mediated signalling and the processes mediated thereby; and the potential for targeting these enzymes to improve the profile of clinical responses. View Full-Text
Keywords: cyclic nucleotides; cAMP; cGMP; phosphodiesterase; PDE3; intracellular signalling; heart cyclic nucleotides; cAMP; cGMP; phosphodiesterase; PDE3; intracellular signalling; heart
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Movsesian, M.; Ahmad, F.; Hirsch, E. Functions of PDE3 Isoforms in Cardiac Muscle. J. Cardiovasc. Dev. Dis. 2018, 5, 10.

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