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J. Cardiovasc. Dev. Dis. 2018, 5(1), 10; https://doi.org/10.3390/jcdd5010010

Functions of PDE3 Isoforms in Cardiac Muscle

1
Department of Internal Medicine/Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT 841132, USA
2
Vascular Biology and Hypertension Branch, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
3
Department of Molecular Biotechnology and Health Sciences, Center for Molecular Biotechnology, University of Turin, 10126 Turin, Italy
Beginning 18 February 2018: Sidra Medical Research Center, Doha, Qatar.
*
Author to whom correspondence should be addressed.
Received: 9 January 2018 / Revised: 30 January 2018 / Accepted: 1 February 2018 / Published: 6 February 2018
(This article belongs to the Special Issue Cyclic Nucleotide Signaling and the Cardiovascular System)
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Abstract

Isoforms in the PDE3 family of cyclic nucleotide phosphodiesterases have important roles in cyclic nucleotide-mediated signalling in cardiac myocytes. These enzymes are targeted by inhibitors used to increase contractility in patients with heart failure, with a combination of beneficial and adverse effects on clinical outcomes. This review covers relevant aspects of the molecular biology of the isoforms that have been identified in cardiac myocytes; the roles of these enzymes in modulating cAMP-mediated signalling and the processes mediated thereby; and the potential for targeting these enzymes to improve the profile of clinical responses. View Full-Text
Keywords: cyclic nucleotides; cAMP; cGMP; phosphodiesterase; PDE3; intracellular signalling; heart cyclic nucleotides; cAMP; cGMP; phosphodiesterase; PDE3; intracellular signalling; heart
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Movsesian, M.; Ahmad, F.; Hirsch, E. Functions of PDE3 Isoforms in Cardiac Muscle. J. Cardiovasc. Dev. Dis. 2018, 5, 10.

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