Frailty in Cardiac Surgery—Assessment Tools, Impact on Outcomes, and Optimisation Strategies: A Narrative Review
Abstract
:1. Introduction
2. Methods
3. Risk Stratification in Cardiac Surgery
4. Measurement Tools to Assess Frailty
- Gait speed
- 2.
- Clinical Frailty Scale
- 3.
- Fried frailty phenotype
- 4.
- Deficit accumulation frailty index
- 5.
- Short Physical Performance Battery (SPPB)
Frailty Measurement Tools | Description | Components | Frailty Defined as | |
---|---|---|---|---|
1 | Clinical Frailty Score (Rockwood) [24,25,26,27] | Evaluates frailty and overall fitness using clinical judgement, assessing the patient based on mobility, independence, and physical activity. | (1) Very fit. | Score of ≥5 |
(2) Well: no active disease symptoms, exercise/active ocassionally. | ||||
(3) Manageing well: medical problems well controlled, not regularly active. | ||||
(4) Vulnerable: not dependent on others, often symptoms limit activities. | ||||
(5) Mildly frail: more evident slowing, need help in high-order instrumental ADLs. | ||||
(6) Moderately frail: requires help with all outside activities and keeping house. Inside, they often need help with bathing. | ||||
(7) Completely dependent for personal care. | ||||
(8) Very severely frail: completely dependent, approaching the end of life. | ||||
(9) Terminally ill: approaching the end of life. Life expectancy <6 months. | ||||
2 | Fried frailty phenotype [27,29] | Evaluates physical frailty. | Assess frailty using five characteristics: poor endurance, slow gait, unintentional weight loss, weak grip strength, and low physical activity. | Score of 1–2 = pre-frailty |
Score of 3–5 = frailty | ||||
3 | Deficit accumulation frailty index (Rockwood) [31,32,34] | Quantifies frailty based on the accumulation of health deficits. | Quantifies the total burden of health deficits across multiple clinical domains (e.g., diagnoses, disability, cognitive function, and physical function) as a proportion. | Pre-frail (FI 0.15 ≤ 0.25) |
Mild to moderate (FI 0.25–0.40) | ||||
Severely frail (FI > 0.40) | ||||
4 | Short Physical Performance Battery [36,37] | Three-part physical performance-based test that evaluates three timed tasks. | (1) Standing balance. | Score of ≤8 (male) and ≤7 (female) |
(2) Repeated chair stands. | ||||
(3) Gait speed. | ||||
5 | Gait speed [16] | Assessed on its own or as part of a multicomponent frailty assessment. | (1) The time required to walk a given distance of 4 or 5 m at a steady walking speed. | Gait speed of <0.83 m per second |
(2) An endurance test assessing the distance covered within a 6 min walk test. | ||||
6 | Comprehensive assessment of frailty (CAF) score [10] | Includes age-related factors in addition to clinical and laboratory data to assess the perioperative risk. | Combination of characteristics of (1) Fried criteria: weakness, self-reported exhaustion, slowness of gait speed, and activity level; (2) physical performance: standing balance and body control; and (2) laboratory results: serum albumin, creatinine, brain natriuretic peptide (BNP), and forced expiratory volume in 1 s (FEV1). | Moderately frail: 11–25 points |
Severely frail: 26–35 points | ||||
7 | Johns Hopkins Adjusted Clinical Groups frailty indicator [41] | Instrument based on 10 clusters of frailty-defining diagnoses. | Malnutrition, dementia, impaired vision, decubitus ulcer, incontinence of urine, loss of weight, poverty, barriers to access to care, difficulty in walking, and falls. | Presence of ≥1 diagnostic clusters |
8 | Frailty predicts death one year after cardiac surgery test (FORECAST) score [42] | A simplified version of the CAF using 5 components. | Chair rise × 3. | Score > 5 |
Subjective reported weakness. | ||||
Serum creatinine. | ||||
Stair climb assessment. | ||||
Clinical Frailty Scale (scored by two doctors). | ||||
9 | Essential Frailty Toolset (EFT) [43] | A combination of physical, cognitive, and biochemical markers. | Timed chair rises (lower-extremity muscle weakness). | 0 (least frail) to 5 (most frail) |
Mini-mental status examination (cognitive impairement). | ||||
Serum albumin (hypoalbuminaemia) and haemoglobin (anaemia). |
5. Impact on Surgical Outcomes
5.1. Primary Outcomes: Short-Term and Long-Term Mortality
5.2. Length of Stay in Hospital
5.3. Secondary Outcomes
5.4. Discharge Need for Rehabilitation
5.5. Quality of Life
6. Optimisation of Frail Patients Undergoing Cardiac Surgery
6.1. Pre-Operative Interventions
6.1.1. Multidisciplinary Geriatric Co-Management
6.1.2. Nutrition
6.1.3. Cardiac Prehabilitation
6.1.4. Decision for Non-Operative Management
6.2. Post-Operative Interventions
6.2.1. Nutrition
6.2.2. Post-Operative Delirium
6.2.3. Rehabilitation
6.2.4. Occupational Therapy
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Pre-Operative | Post-Operative |
---|---|
Frailty Screening | Early recognition, prevention, and treatment of post-operative delirium |
Multidisciplinary ‘Heart’ Team | Optimising nutrition |
Geriatric Assessment | Early Cardiac Rehabilitation |
Cardiac Prehabilitation | Early Occupational Therapy |
Nutrition Status |
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Chandiramani, A.; Ali, J.M. Frailty in Cardiac Surgery—Assessment Tools, Impact on Outcomes, and Optimisation Strategies: A Narrative Review. J. Cardiovasc. Dev. Dis. 2025, 12, 127. https://doi.org/10.3390/jcdd12040127
Chandiramani A, Ali JM. Frailty in Cardiac Surgery—Assessment Tools, Impact on Outcomes, and Optimisation Strategies: A Narrative Review. Journal of Cardiovascular Development and Disease. 2025; 12(4):127. https://doi.org/10.3390/jcdd12040127
Chicago/Turabian StyleChandiramani, Ashwini, and Jason M. Ali. 2025. "Frailty in Cardiac Surgery—Assessment Tools, Impact on Outcomes, and Optimisation Strategies: A Narrative Review" Journal of Cardiovascular Development and Disease 12, no. 4: 127. https://doi.org/10.3390/jcdd12040127
APA StyleChandiramani, A., & Ali, J. M. (2025). Frailty in Cardiac Surgery—Assessment Tools, Impact on Outcomes, and Optimisation Strategies: A Narrative Review. Journal of Cardiovascular Development and Disease, 12(4), 127. https://doi.org/10.3390/jcdd12040127