The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population/Trial Design
2.2. Anthropometry Measurements
2.3. Blood Pressure Variability
2.4. Plasma Inflammatory Marker Measurement
2.5. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. Associations Between BPV and Inflammation
4. Discussion
4.1. Diastolic BPV
4.2. Systolic BPV
4.3. Inflammatory Cytokines
4.4. Limitations
4.5. Implications
4.6. Future Steps
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
BPV | Blood pressure variation |
ABPM | Ambulatory blood pressure monitoring |
ABP | Ambulatory blood pressure |
CVD | Cardiovascular disease |
CRP | C-reactive Protein |
IL-6 | Interleukin-6 |
TNF-α | Tumor necrosis factor alpha |
GSH | Georgia Stress and Heart |
ARV | Average Real Variability |
GEE | Generalized Estimating Equations |
QIC | Quasi-likelihood under the Independence model Criterion |
IFN-γ | Interferon-gamma |
SBP | Systolic blood pressure |
DBP | Diastolic blood pressure |
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Characteristic | Visit 13–15 All Patients (n = 447) | 1 Visit (n = 144) | 2 Visits (n = 210) | 3 Visits (n = 93) | p-Value |
---|---|---|---|---|---|
Age, years | 22.90 ± 3.11 | 23.63 ± 3.21 | 23.69 ± 3.19 | 21.34 ± 2.21 | <0.01 * |
Sex, n (%) | |||||
-Male | 212 (47.43%) | 67 (46.53%) | 104 (49.52%) | 41 (44.09%) | - |
-Female | 235 (52.57%) | 77 (53.47%) | 106 (50.48%) | 52 (55.91%) | - |
Race, n (%) | |||||
Non-Hispanic White | 210 (46.98%) | 64 (44.44%) | 92 (43.81%) | 54 (58.06%) | - |
Non-Hispanic Black | 237 (53.02%) | 80 (55.56%) | 118 (56.19%) | 39 (41.94%) | - |
Mean Systolic BP, mmHg | 118.44 ± 9.62 | 119.93 ± 11.19 | 118.95 ± 9.43 | 116.91 ± 8.83 | <0.01 * |
Mean Diastolic BP, mmHg | 70.74 ± 7.50 | 72.19 ± 8.84 | 71.13 ± 7.67 | 69.40 ± 6.20 | <0.01 * |
20 h BPV Systolic BP | 7.75 ± 1.41 | 7.87 ± 1.71 | 7.72 ± 1.28 | 7.74 ± 1.46 | 0.74 |
Daytime BPV Systolic BP | 7.79 ± 1.65 | 7.91 ± 1.90 | 7.72 ± 1.59 | 7.85 ± 1.63 | 0.53 |
Nighttime BPV Systolic BP | 7.80 ± 2.52 | 7.66 ± 2.43 | 8.02 ± 1.28 | 7.54 ± 2.48 | 0.08 |
20 h BPV Diastolic BP | 7.62 ± 1.50 | 7.73 ± 1.60 | 7.65 ± 1.46 | 7.53 ± 1.51 | 0.59 |
Daytime BPV Diastolic BP | 7.79 ± 1.77 | 7.84 ± 1.86 | 7.83 ± 1.75 | 7.71 ± 1.77 | 0.73 |
Nighttime BPV Diastolic BP | 7.49 ± 2.54 | 7.55 ± 2.41 | 7.65 ± 2.17 | 7.23 ± 2.46 | 0.17 |
CRP Serum Concentration mg/L | 3.39 × 10−3 ± 7.25 × 10−3 | 4.06 × 10−3 ± 1.06 × 10−2 | 3.51 × 10−3 ± 7.45 × 10−3 | 2.84 × 10−3 ± 4.15 × 10−3 | 0.54 |
IL6 Serum Concentration pg/mL | 3.83 ± 7.38 | 5.75 ± 10.50 | 3.65 ± 7.90 | 2.97 ± 1.88 | 0.20 |
TNF-α Serum Concentration pg/mL | 6.30 ± 5.39 | 6.10 ± 1.31 | 6.58 ± 7.27 | 5.94 ± 1.35 | 0.56 |
IFN-γ Serum Concentration pg/mL | 0.87 ± 1.17 | 0.90 ± 1.28 | 0.94 ± 1.38 | 0.75 ± 0.55 | 0.46 |
Variable | Estimate (β) | Standard Error | 95% Confidence Interval | p-Value |
---|---|---|---|---|
CRP | ||||
| 0.048 | 0.03 | −0.010, 0.107 | 0.104 |
| 0.017 | 0.019 | −0.020, 0.054 | 0.364 |
| 0.019 | 0.013 | −0.006, 0.045 | 0.136 |
| 0.076 | 0.023 | 0.031, 0.120 | 0.001 * |
| 0.054 | 0.017 | 0.020, 0.088 | 0.002 * |
| 0.028 | 0.012 | 0.005, 0.052 | 0.020 * |
IFN-γ | ||||
| 0.002 | 0.016 | −0.029, 0.034 | 0.886 |
| −0.005 | 0.013 | −0.030, 0.020 | 0.677 |
| −0.003 | 0.007 | −0.016, 0.010 | 0.655 |
| −0.003 | 0.011 | −0.025, 0.018 | 0.765 |
| −0.006 | 0.011 | −0.027, 0.016 | 0.605 |
| −0.001 | 0.007 | −0.013, 0.013 | 0.986 |
TNF-α | ||||
| 0.004 | 0.005 | −0.006, 0.014 | 0.357 |
| 0.000 | 0.004 | −0.007, 0.006 | 0.747 |
| −0.001 | 0.002 | −0.005, 0.003 | 0.443 |
| 0.011 | 0.005 | 0.002, 0.021 | 0.015 * |
| 0.003 | 0.003 | −0.003, 0.009 | 0.915 |
| 0.006 | 0.002 | 0.002, 0.010 | 0.007 * |
IL6 | ||||
| 0.008 | 0.013 | −0.018, 0.035 | 0.546 |
| 0.008 | 0.009 | −0.009, 0.026 | 0.350 |
| −0.004 | 0.007 | −0.017, 0.010 | 0.574 |
| 0.018 | 0.011 | −0.004, 0.040 | 0.110 |
| 0.010 | 0.009 | −0.009, 0.028 | 0.309 |
| 0.011 | 0.008 | −0.004, 0.026 | 0.150 |
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Weeks, C.J.; Bekele, B.B.; Altvater, M.; Cheng, J.; Zhu, H.; Huang, Y.; Jehu, D.A.; Simon, A.B.; Li, W.; Dong, Y. The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults. J. Cardiovasc. Dev. Dis. 2025, 12, 399. https://doi.org/10.3390/jcdd12100399
Weeks CJ, Bekele BB, Altvater M, Cheng J, Zhu H, Huang Y, Jehu DA, Simon AB, Li W, Dong Y. The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults. Journal of Cardiovascular Development and Disease. 2025; 12(10):399. https://doi.org/10.3390/jcdd12100399
Chicago/Turabian StyleWeeks, Charles J., Bayu B. Bekele, Michelle Altvater, Jie Cheng, Haidong Zhu, Ying Huang, Deborah A. Jehu, Abigayle B. Simon, Wenjun Li, and Yanbin Dong. 2025. "The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults" Journal of Cardiovascular Development and Disease 12, no. 10: 399. https://doi.org/10.3390/jcdd12100399
APA StyleWeeks, C. J., Bekele, B. B., Altvater, M., Cheng, J., Zhu, H., Huang, Y., Jehu, D. A., Simon, A. B., Li, W., & Dong, Y. (2025). The Association Between Short-Term Blood Pressure Variability and Inflammation in Healthy Young Adults. Journal of Cardiovascular Development and Disease, 12(10), 399. https://doi.org/10.3390/jcdd12100399