Impact of Atrial Fibrillation on the Outcome of Patients with Brugada Syndrome: A Meta-Analysis
Abstract
1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Eligibility Criteria and Population
2.3. Outcomes of Interest
2.4. Data Extraction
2.5. Statistical Analysis
2.6. Sensitivity Analysis
2.7. Risk of Bias Assessment
Study | Takagi 2007 [16] | Kusano 2008 [17] | Cabanelas 2013 [18] | Giustetto 2014 [19] | Calò 2016 [20] | Tokioka 2017 [21] | Asmundis 2017 [22] | Sieira 2017 [23] | Tse 2020 [24] | Honarbakhsh 2021 [25] | Migliore 2022 [26] | Gaita 2023 [27] | Kamakura 2024 [28] | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Characteristic | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF | +AF | −AF |
Study design | Prospective cohort | Prospective cohort | Prospective cohort | Prospective cohort | Prospective cohort | Retrospective cohort | Retrospective cohort | Prospective cohort | Retrospective cohort | Retrospective cohort | Retrospective cohort | Prospective cohort | Prospective cohort | |||||||||||||
Country | Japan | Japan | N/A | Italy | Italy | Japan | Belgium | Brussels | Hong Kong | International | Italy & Belgium | Italy | Japan | |||||||||||||
Single/Multicentre | Multicentre | Single centre | N/A | Multi centre | Multi centre | Single centre | Single centre | Single centre | Multicentre | Multicentre | Multicentre | Multicentre | Multicentre | |||||||||||||
No. patients | 32 | 156 | 10 | 63 | 14 | 264 | 48 | 512 | 18 | 329 | 44 | 202 | 31 | 258 | 31 | 349 | 14 | 261 | 79 | 1031 | 25 | 80 | 18 | 1131 | 68 | 345 |
Age (years) | 53 | 49 | 43.7 | Group 1–47 Group 2–59 Group 3–44 | 45 | 47.6 | 45 | 41.1 | 53 | 51.8 | 45 | 45 | 50.9 | |||||||||||||
Male (%) | 94.7 | 98.6 | N/A | 75.7 | 78.4 | 95.9 | 70.2 | 58.3 | 90 | 71.8 | 75 | 74 | 95.6 | |||||||||||||
Brugada type | Spontaneous or drug-induced type 1 | Spontaneous or drug-induced type 1 | N/A | Spontaneous or drug-induced type 1 | Spontaneous type 1 | Spontaneous or drug-induced type 1 | Spontaneous or drug-induced type 1 | Spontaneous or drug-induced type 1 | Spontaneous or fever-induced type 1 | Spontaneous or drug-induced type 1 | Spontaneous or drug-induced type 1 | Spontaneous or drug-induced type 1 | Spontaneous or drug-induced type 1 | |||||||||||||
AF type prevalence (%) | Paroxysmal 17% | Paroxysmal 13.7% | N/A | Persistent & paroxysmal 9% | Persistent and paroxysmal 5.2% | Paroxysmal 17.9% | Paroxysmal 10.7% | N/A | Paroxysmal, persistent & permanent 5% | N/A | Paroxysmal 24% | N/A | N/A | |||||||||||||
MAE definition | VF and SCD | VF | VF/polymorphic VT | SCD, VF, and appropriate shock | SCD, aborted SCD, VF, and sVT | SCD, VF, and appropriate shock | SCD and appropriate shock | SCD | VT and VF | SCD, VT, and VF | VT and VF | SCD, VT, and VF | VF | |||||||||||||
Follow-up period (months) | Mean 37 ± 16 | N/A | Mean 59.3 ± 49.4 | Median Group 1–46 Group 2–68 Group 3–41 | Mean 48 ± 38.6 | Mean 45.1 ± 44.3 | Mean 120 ± 55.7 | Mean 80.7 ± 57.2 | Median 67 (31–113) | Median 63.96 ± 48 | Median 155 (128–181) | Median 72 (48–108) | 106.8 ± 66.1 |
3. Results
3.1. Characteristics of Included Studies
3.2. Study Appraisal
3.3. Meta-Analysis of Extracted Data
4. Discussion
4.1. AF Occurrence
4.2. Clinical Implications
4.3. Genetics
4.4. Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AF | Atrial fibrillation |
BrS | Brugada syndrome |
MAE | Major arrhythmic event |
SCD | Sudden cardiac death |
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Aboutorabi, M.; Ahmad, M.; Bray, J.J.H.; Gomes, D.A.; Providencia, R. Impact of Atrial Fibrillation on the Outcome of Patients with Brugada Syndrome: A Meta-Analysis. J. Cardiovasc. Dev. Dis. 2025, 12, 391. https://doi.org/10.3390/jcdd12100391
Aboutorabi M, Ahmad M, Bray JJH, Gomes DA, Providencia R. Impact of Atrial Fibrillation on the Outcome of Patients with Brugada Syndrome: A Meta-Analysis. Journal of Cardiovascular Development and Disease. 2025; 12(10):391. https://doi.org/10.3390/jcdd12100391
Chicago/Turabian StyleAboutorabi, Max, Mahmood Ahmad, Jonathan J. H. Bray, Daniel A. Gomes, and Rui Providencia. 2025. "Impact of Atrial Fibrillation on the Outcome of Patients with Brugada Syndrome: A Meta-Analysis" Journal of Cardiovascular Development and Disease 12, no. 10: 391. https://doi.org/10.3390/jcdd12100391
APA StyleAboutorabi, M., Ahmad, M., Bray, J. J. H., Gomes, D. A., & Providencia, R. (2025). Impact of Atrial Fibrillation on the Outcome of Patients with Brugada Syndrome: A Meta-Analysis. Journal of Cardiovascular Development and Disease, 12(10), 391. https://doi.org/10.3390/jcdd12100391