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Article

Freedom from Recurrence across Age in Non-Melanoma Skin Cancer Treated with Image-Guided Superficial Radiation Therapy

by
Aaron S. Farberg
1,2,
Randy V. Heysek
3,
Robert Haber
4,
Rania Agha
5,6,7,
Kevin M. Crawford
8,9,
Ji Xinge
10 and
Jeffrey Blake Stricker
11,12,13,*
1
Bare Dermatology, Dallas, TX 75235, USA
2
University of North Texas Health Science Center, University of North Texas, Fort Worth, TX 76107, USA
3
Central Florida Cancer Institute, Davenport, FL 33837, USA
4
Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
5
Department of Dermatology, The University of Illinois at Chicago, Chicago, IL 60607, USA
6
Jesse Brown VA Medical Center, Chicago, IL 60612, USA
7
Department of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
8
Department of Dermatology, Marian University College of Osteopathic Medicine, Indianapolis, IN 46222, USA
9
Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
10
Independent Researcher, Champaign, IL 61822, USA
11
Dermatology Specialists of Alabama, Dothan, AL 36303, USA
12
Alabama College of Osteopathic Medicine, Dothan, AL 36303, USA
13
Southeast Health Internal Medicine Residency, Dothan, AL 36301, USA
 
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*
Author to whom correspondence should be addressed.
Geriatrics 2024, 9(5), 114; https://doi.org/10.3390/geriatrics9050114
Submission received: 17 June 2024 / Revised: 23 July 2024 / Accepted: 29 July 2024 / Published: 5 September 2024
(This article belongs to the Section Geriatric Oncology)
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Abstract

Non-melanoma skin cancers (NMSCs) are a significant cause of morbidity and mortality; their incidence is increasing most in older patients. NMSCs have traditionally been treated with surgical excision, curettage, Mohs micrographic surgery (MMS), and superficial radiotherapy (SRT). Image-guided SRT (IGSRT) is a treatment option for poor surgical candidates or patients with low- or high-risk, early-stage NMSC who prefer to avoid surgery. This large retrospective cohort study compared 2-, 4-, and 6-year freedom from recurrence in biopsy-proven NMSC lesions treated with IGSRT (n = 20,069 lesions) between patients aged < 65 years (n = 3158 lesions) and ≥65 years (n = 16,911 lesions). Overall freedom from recurrence rates were 99.68% at 2 years, 99.57% at 4 years, and 99.57% at 6 years. Rates did not differ significantly by age (p = 0.8) nor by sex among the two age groups (p > 0.9). There was a significant difference in recurrence among older patients when analyzed by stage (p = 0.032), but no difference by stage in younger patients (p = 0.7). For early-stage NMSCs, IGSRT is a clinically equivalent alternative to MMS and statistically significant in superiority to non-image-guided SRT. This study demonstrates that there is no significant effect of age on 2-, 4-, or 6-year freedom from recurrence in patients with IGSRT-treated NMSC.
Keywords: non-melanoma skin cancer; image-guided superficial radiation therapy; freedom from recurrence; age; sex; stage non-melanoma skin cancer; image-guided superficial radiation therapy; freedom from recurrence; age; sex; stage

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MDPI and ACS Style

Farberg, A.S.; Heysek, R.V.; Haber, R.; Agha, R.; Crawford, K.M.; Xinge, J.; Stricker, J.B. Freedom from Recurrence across Age in Non-Melanoma Skin Cancer Treated with Image-Guided Superficial Radiation Therapy. Geriatrics 2024, 9, 114. https://doi.org/10.3390/geriatrics9050114

AMA Style

Farberg AS, Heysek RV, Haber R, Agha R, Crawford KM, Xinge J, Stricker JB. Freedom from Recurrence across Age in Non-Melanoma Skin Cancer Treated with Image-Guided Superficial Radiation Therapy. Geriatrics. 2024; 9(5):114. https://doi.org/10.3390/geriatrics9050114

Chicago/Turabian Style

Farberg, Aaron S., Randy V. Heysek, Robert Haber, Rania Agha, Kevin M. Crawford, Ji Xinge, and Jeffrey Blake Stricker. 2024. "Freedom from Recurrence across Age in Non-Melanoma Skin Cancer Treated with Image-Guided Superficial Radiation Therapy" Geriatrics 9, no. 5: 114. https://doi.org/10.3390/geriatrics9050114

APA Style

Farberg, A. S., Heysek, R. V., Haber, R., Agha, R., Crawford, K. M., Xinge, J., & Stricker, J. B. (2024). Freedom from Recurrence across Age in Non-Melanoma Skin Cancer Treated with Image-Guided Superficial Radiation Therapy. Geriatrics, 9(5), 114. https://doi.org/10.3390/geriatrics9050114

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