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Psychological Wellbeing and Healthy Aging: Focus on Telomeres

Department of Psychiatry, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
Section of Gerontology and Geriatrics, Santa Maria della Misericordia Hospital, 60132 Perugia, Italy
Author to whom correspondence should be addressed.
Geriatrics 2019, 4(1), 25;
Received: 2 January 2019 / Revised: 9 February 2019 / Accepted: 18 February 2019 / Published: 23 February 2019
PDF [225 KB, uploaded 23 February 2019]


Stress and depression are known to modulate the aging process, and might also affect telomere biology. In fact, exposure to some biochemical pathways involved in stress-related depression may contribute to an ‘‘accelerated aging” phenotype, as well as the incidence of age-related diseases, including metabolic disorders and dementia. Basic studies support the notion that the telomere and telomerase system plays a pivotal role in the aging process and disease promotion. Interestingly, short and dysfunctional telomeres are associated with reduced lifespan, as shown in animal models. In this context, telomeres are very sensitive to stress, mindset, and lifestyle, and their rescue may be sufficient to restore cell and organism viability. This mini-review discusses conceptual models of healthy and active aging and their relationship with telomere biology and mental health. View Full-Text
Keywords: wellbeing; aging; telomeres; stress; longevity wellbeing; aging; telomeres; stress; longevity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Boccardi, M.; Boccardi, V. Psychological Wellbeing and Healthy Aging: Focus on Telomeres. Geriatrics 2019, 4, 25.

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