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Article

Associations between Intra-Individual Variability of Reaction Time and Cognitive Function in Cognitively Normal Senior Adults: Still beyond Good or Bad?

1
Department of Psychiatry, The Chinese University of Hong Kong, G/F Multicenter, Tai Po Hospital 100000, Hong Kong, China
2
Department of Psychiatry, Guangzhou Brain Hospital, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China
*
Author to whom correspondence should be addressed.
Academic Editor: Joaquim Cerejeira
Geriatrics 2016, 1(2), 13; https://doi.org/10.3390/geriatrics1020013
Received: 24 March 2016 / Revised: 29 May 2016 / Accepted: 31 May 2016 / Published: 3 June 2016
(This article belongs to the Special Issue Medical Disorders and Cognition in the Elderly)
Background: Intra-individual (IIV) of reaction time (RT), as the short-term fluctuations of RT-based performance, has been reported to be susceptible to cognitive ageing. The current study aimed to examine IIV of RT and its relationships with cognitive performance in cognitively normal senior adults. Methods: We evaluated 137 community-dwelling elderly (mean age: 72.41 ± 3.99) with a comprehensive neuropsychological battery and a RT-based test. Intraindividual coefficient of variation of reaction time (ICV-RT) was used to evaluate the IIV. Pearson’s correlation and hierarchical multiple regression analyses were employed to assess the relationships between IIV and the scores of cognitive function. Results: Advancing age was accompanied with declined cognitive function and increased IIV. ICV-RT was negatively correlated with the score of Montreal Cognitive Assessment Hong Kong version (HK MoCA) across three types of flanker. Hierarchical multiple regression showed that ICV-RT was a significant predictor of HK MoCA (β = −0.294, p = 0.001). Conclusion: Increased IIV is consistently associated with and contributed to the age-related decline of cognitive performance in senior adults. The utility of IIV in predicting further deterioration should be carefully postulated with prospective studies. View Full-Text
Keywords: intra-individual variability; short-term fluctuations; MoCA; reaction time; cognitive ageing; age-related cognitive decline intra-individual variability; short-term fluctuations; MoCA; reaction time; cognitive ageing; age-related cognitive decline
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MDPI and ACS Style

Lu, H.; Chan, S.S.M.; Lam, L.C.W. Associations between Intra-Individual Variability of Reaction Time and Cognitive Function in Cognitively Normal Senior Adults: Still beyond Good or Bad? Geriatrics 2016, 1, 13. https://doi.org/10.3390/geriatrics1020013

AMA Style

Lu H, Chan SSM, Lam LCW. Associations between Intra-Individual Variability of Reaction Time and Cognitive Function in Cognitively Normal Senior Adults: Still beyond Good or Bad? Geriatrics. 2016; 1(2):13. https://doi.org/10.3390/geriatrics1020013

Chicago/Turabian Style

Lu, Hanna, Sandra S.M. Chan, and Linda C.W. Lam 2016. "Associations between Intra-Individual Variability of Reaction Time and Cognitive Function in Cognitively Normal Senior Adults: Still beyond Good or Bad?" Geriatrics 1, no. 2: 13. https://doi.org/10.3390/geriatrics1020013

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