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Open AccessCase Report

Anaplastic Mammary Carcinoma in Cat

CIISA, Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Av. da Universidade Técnica, 1300-477 Lisboa, Portugal
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Author to whom correspondence should be addressed.
Present address: Faculdade de Medicina Veterinária, Universidade Lusófona de Humanidades e Tecnologia, Campo Grande 376, 1749-024 Lisboa, Portugal.
Academic Editor: Paolo Emidio Crisi
Vet. Sci. 2021, 8(5), 77; https://doi.org/10.3390/vetsci8050077
Received: 21 April 2021 / Revised: 27 April 2021 / Accepted: 2 May 2021 / Published: 4 May 2021
(This article belongs to the Special Issue Advances in Feline Internal Medicine)
Clinical, pathological, and immunohistochemical findings related to a feline mammary tumor with similar features to canine anaplastic mammary carcinoma are herein described for the first time. A female cat was presented for clinical evaluation with gastrointestinal signs, oedema, erythema, and painful lesion in the right inguinal region. Three weeks later, the mass had doubled in size and radiographic revaluation of the thoracic cavity revealed a metastatic pattern. Due to the poor prognosis and decline of the clinical status the owners decided for euthanasia. Post-mortem examination exposed a mammary tumoral mass with subcutaneous oedema, an enlargement of the right inguinal lymph node, and nodules in several organs. Histological analysis confirmed the presence of large pleomorphic epithelial cells, often grouped in small clusters with bizarre nuclei. Immunohistochemical study of the different lesions was performed and both primary tumor and regional metastasis showed tumor cells to be negative estrogen receptor alpha, positive progesterone receptor, positive HER-2, and positive pan-cytokeratin. Given that the clinical history was compatible with an inflammatory mammary carcinoma, the cyclooxygenase-2 expression levels were evaluated and presented a weak immunoreactivity. Regarding the distant metastatic lesions, tumor cells were negative for ER-α and PR and, positive both for HER-2 and pan-cytokeratin. View Full-Text
Keywords: anaplastic; feline mammary carcinoma; clinicopathological; immunohistochemical anaplastic; feline mammary carcinoma; clinicopathological; immunohistochemical
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MDPI and ACS Style

Soares, M.; Correia, J.; Nascimento, C.; Ferreira, F. Anaplastic Mammary Carcinoma in Cat. Vet. Sci. 2021, 8, 77. https://doi.org/10.3390/vetsci8050077

AMA Style

Soares M, Correia J, Nascimento C, Ferreira F. Anaplastic Mammary Carcinoma in Cat. Veterinary Sciences. 2021; 8(5):77. https://doi.org/10.3390/vetsci8050077

Chicago/Turabian Style

Soares, Maria; Correia, Jorge; Nascimento, Catarina; Ferreira, Fernando. 2021. "Anaplastic Mammary Carcinoma in Cat" Vet. Sci. 8, no. 5: 77. https://doi.org/10.3390/vetsci8050077

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