MicroRNAs as Biomarkers in Canine Osteosarcoma: A New Future?
Abstract
:1. Introduction
2. Canine Osteosarcoma
3. What Are MicroRNAs?
3.1. Biogenesis of MiRNAs
3.2. MiRNAs as Biomarkers
4. MiRNAs in Canine Osteosarcoma Cells
4.1. miR-1 and miR-133b
4.2. miR-9
4.3. miR-196a
4.4. MicroRNAs in the 14q32 Locus
4.5. miR-34a
4.6. Cluster of miR-106b-25 (miR-106b, miR-25 and miR-93-5p)
5. Circulating MicroRNAs and Their Potential as Non-Invasive Biomarkers
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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miRNAs | Expression Profiles in OSA | Target Genes or Proteins | Result of Aberrant miRNA Expression | Possible Uses |
---|---|---|---|---|
miR-1 and miR-133b | Reduced expression | MET and MCL1 | Cell proliferation and growth Cancer cells Invasion Cancer cells Survival Inhibition of apoptosis | Diagnostic biomarker for canine OSA |
miR-9 | Overexpression | Gelsolin | Cell motility and invasive capacity increase Promotion of metastasis | Possible prognostic biomarker |
miR-196a | Reduced expression | Annexin 1 | Facilitates migration and invasion Cancer cells adhesion and migration Mediates VEGF1 induced cell migration | Potential prognostic biomarker |
14q32 locus (miR-544, miR-369-3p, miR-134 and miR-382) | Reduced levels | cMYC | Promotion of metastasis Poorer survival rates Inhibition of apoptosis Tumorigenesis maintenance | Potential prognostic biomarker Potential therapeutic target |
miR-34a | Reduced levels | MET, SIRT1, CDK6, VEGF1 | Mediates VEGF1 induced cell migration Shorter disease-free survival times | Potential prognostic biomarker Potential therapeutic target |
miR-106b-25 cluster (miR-106b, miR-25 and miR-93-5p) | Overexpression | p21 | Cell proliferation and growth Cancer cells Invasion Cell cycle promotors Activation of tumorigenesis | Potential prognostic biomarker |
Circulating miR-214 | Increased levels in circulation | Shorter survival times | Potential non-invasive predictive biomarker | |
Circulating miR-126 | Increased levels in circulation | Longer survival times | Potential non-invasive predictive biomarker |
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Gourbault, O.; Llobat, L. MicroRNAs as Biomarkers in Canine Osteosarcoma: A New Future? Vet. Sci. 2020, 7, 146. https://doi.org/10.3390/vetsci7040146
Gourbault O, Llobat L. MicroRNAs as Biomarkers in Canine Osteosarcoma: A New Future? Veterinary Sciences. 2020; 7(4):146. https://doi.org/10.3390/vetsci7040146
Chicago/Turabian StyleGourbault, Olivia, and Lola Llobat. 2020. "MicroRNAs as Biomarkers in Canine Osteosarcoma: A New Future?" Veterinary Sciences 7, no. 4: 146. https://doi.org/10.3390/vetsci7040146
APA StyleGourbault, O., & Llobat, L. (2020). MicroRNAs as Biomarkers in Canine Osteosarcoma: A New Future? Veterinary Sciences, 7(4), 146. https://doi.org/10.3390/vetsci7040146