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Atopic Dermatitis in Animals and People: An Update and Comparative Review

Department of Dermatology, College of Medicine, University of Florida, 4037 NW 86 Terrace, Gainesville, FL 32606, USA
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32610, USA
Author to whom correspondence should be addressed.
Academic Editor: Rob Siebers
Vet. Sci. 2017, 4(3), 37;
Received: 13 June 2017 / Revised: 20 July 2017 / Accepted: 22 July 2017 / Published: 26 July 2017
(This article belongs to the Special Issue Allergies in Animals and Humans)
PDF [1531 KB, uploaded 26 July 2017]


Atopic dermatitis is an extremely common, pruritic, and frustrating disease to treat in both people and animals. Atopic dermatitis is multifactorial and results from complex interactions between genetic and environmental factors. Much progress has been done in recent years in terms of understanding the complex pathogenesis of this clinical syndrome and the identification of new treatments. As we learn more about it, we appreciate the striking similarities that exist in the clinical manifestations of this disease across species. Both in animals and people, atopic disease is becoming increasingly common and important similarities exist in terms of immunologic aberrations and the propensity for allergic sensitization. The purpose of this review is to highlight the most recent views on atopic dermatitis in both domestic species and in people emphasizing the similarities and the differences. A comparative approach can be beneficial in understanding the natural course of this disease and the variable response to existing therapies. View Full-Text
Keywords: atopic dermatitis; skin barrier; atopic march; dogs; cats; horses; humans atopic dermatitis; skin barrier; atopic march; dogs; cats; horses; humans

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Marsella, R.; De Benedetto, A. Atopic Dermatitis in Animals and People: An Update and Comparative Review. Vet. Sci. 2017, 4, 37.

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