Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human
Abstract
:1. Introduction
2. Comparative Pathology
3. Gene Changes in Canine and Human MMVD
4. Conclusions
Supplementary Materials
Acknowledgments
Conflicts of Interest
Abbreviations
MMVD | Myxomatous mitral valve disease |
RT-PCR | Real time polymerase chain reaction |
VEC | Valvular endothelial cell |
LAMA | Laminin |
NID | Nidogen |
GAG | Glycosaminoglycan |
VIC | Valvular interstitial cell |
ECM | Extracellular matrix |
FED | Fibroelastic deficiency |
MVP | Mitral valve prolapse |
FDR | False discovery rate |
COL | Collagen |
LUM | Lumican |
VCAN | Versican |
MMP | Matrix-metalloproteinase |
TIMP | Tissue inhibitor of metalloproteinase |
KEGG | Kyoto Encyclopedia of Genes and Genomes |
EndoMT | Endothelial-to-mesenchymal transition |
α-SMA | Alpha-smooth muscle actin |
CD31 | Platelet endothelial cell adhesion molecule 1 |
CDH5 | Vascular endothelial cadherin |
HAS2 | Hyaluronic synthase 2 |
IHC | Immunohistochemistry |
TGF-β | Transforming growth factor–β |
SMAD | Suppressor of mothers against decapentaplegic |
BMP | Bone morphogenetic proteins |
COMP | Cartilage oligomeric matrix protein |
ENG | Endoglin |
TGFBI | TGF-β-induced |
CTGF | Connective tissue growth factor |
5-HT | 5-hydroxytryptamine |
TPH1 | Tryptophan hydroxylase 1 |
AGT2 | Angiotensin 2 |
AT1 | AGT2 type 1 receptor |
ADAMTS | A Disintegrin And Metalloproteinase with Thrombospondin Motifs |
SLRP | Small leucine-rich proteoglycans |
CHAD | Chondroadherin |
KERA | Keratocan |
HAPLN1 | Hyaluronan and proteoglycan link protein 1 |
TNF-α | Tumor necrosis factor α |
NFκB | Nuclear factor kappa-light-chain-enhancer of activated B cells |
LDLR | Lipoprotein receptor |
HSP | Heat shock proteins |
ROS | Reactive oxygen species |
NOX | Nicotinamide adenine dinucleotide phosphate-oxidase |
SOD | Superoxide dismutase |
ncRNAs | Non-coding RNAs |
miRs | MicroRNAs |
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Markby, G.R.; Summers, K.M.; MacRae, V.E.; Corcoran, B.M. Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human. Vet. Sci. 2017, 4, 34. https://doi.org/10.3390/vetsci4030034
Markby GR, Summers KM, MacRae VE, Corcoran BM. Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human. Veterinary Sciences. 2017; 4(3):34. https://doi.org/10.3390/vetsci4030034
Chicago/Turabian StyleMarkby, Greg R., Kim M. Summers, Vicky E. MacRae, and Brendan M. Corcoran. 2017. "Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human" Veterinary Sciences 4, no. 3: 34. https://doi.org/10.3390/vetsci4030034